{"id":"W4319655799","doi":"10.1371/journal.pbio.3001967","title":"Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs","year":2023,"lang":"en","type":"article","venue":"PLoS Biology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Health and Medical Research Council; University of Sydney; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Biology; Spike (software development); Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Receptor; Genetics; Coronavirus disease 2019 (COVID-19); Computational biology; Fibroblast; Cell culture; Internal medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000189287,0.0002329996,0.0004364774,0.0001594743,0.0001826852,0.00003014198,0.0001351658,0.0003568507,0.00007617118],"category_scores_gemma":[0.0001097975,0.000194151,0.000101078,0.000105572,0.000579203,0.00008724579,0.0000682188,0.0001732799,0.0002415249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001030811,"about_ca_system_score_gemma":0.00003415418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002063953,"about_ca_topic_score_gemma":0.000006246767,"domain_scores_codex":[0.9984816,0.0002185734,0.000297314,0.0004637604,0.00002017728,0.0005185156],"domain_scores_gemma":[0.9993628,0.0003029517,0.0000775642,0.0001684997,0.00007102363,0.00001717853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001635794,0.00009986536,0.0009793168,0.00008100451,0.000257134,0.000001021533,0.0003794155,1.578182e-8,0.9867066,0.001270718,0.004334209,0.004254971],"study_design_scores_gemma":[0.003099226,0.001737612,0.001687746,0.0001143765,0.00004558172,0.00002740936,0.0001349777,0.00005306829,0.8828728,0.0005602172,0.109406,0.0002610212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953075,0.001250695,0.0001361551,0.001479706,0.0002907123,0.000844826,0.0004196078,0.0001663216,0.0001044683],"genre_scores_gemma":[0.9967942,0.0001959441,0.0001686421,0.0004204127,0.00004256032,0.0001964177,0.0004955675,0.00002618061,0.001660132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1050718,"threshold_uncertainty_score":0.7917247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04523182525653455,"score_gpt":0.2840850203343026,"score_spread":0.238853195077768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}