{"id":"W4319655799","doi":"10.1371/journal.pbio.3001967","title":"Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs","year":2023,"lang":"en","type":"article","venue":"PLoS Biology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Health and Medical Research Council; University of Sydney; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Biology; Spike (software development); Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Receptor; Genetics; Coronavirus disease 2019 (COVID-19); Computational biology; Fibroblast; Cell culture; Internal medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001279274,0.0002885214,0.0002271733,0.0001534778,0.0001595437,0.0003090632,0.0001287058,0.0002294308,0.00125405],"category_scores_gemma":[0.00008064616,0.0001182577,0.0002308338,0.00009330986,0.0001762419,0.0001470371,0.0002241089,0.0003323748,0.000526598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002883413,"about_ca_system_score_gemma":0.000186151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003695199,"about_ca_topic_score_gemma":0.0007362833,"domain_scores_codex":[0.9998118,0.00002246184,0.00001287527,0.00004781719,0.00006097765,0.00004408001],"domain_scores_gemma":[0.9999405,0.000007089973,0.00002078839,0.000007946376,0.000008415007,0.00001520428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004041813,0.000005350568,0.0002502794,0.00001830141,0.000001885476,0.00005070188,0.000007414486,0.00003476639,0.9985475,0.00009521483,0.0000366773,0.0009113414],"study_design_scores_gemma":[0.00001725973,0.0001740404,0.01293151,0.00001007679,0.00001455236,0.0006788023,0.00007423599,0.001642296,0.9765447,0.0001167455,0.007786702,0.00000906374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828793,0.00254413,0.008643046,0.0001901685,0.00005759871,0.00003603356,0.0009197118,0.000238146,0.004491659],"genre_scores_gemma":[0.9911465,0.0007642484,0.003492857,0.00009348577,0.00001078215,0.00001986782,0.0009447312,0.00002850448,0.003499001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00125405,"threshold_uncertainty_score":0.004195213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04523182525653455,"score_gpt":0.2840850203343026,"score_spread":0.238853195077768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}