{"id":"W4319660667","doi":"10.1016/s0140-6736(22)02574-0","title":"Adjuvant nivolumab plus ipilimumab versus placebo for localised renal cell carcinoma after nephrectomy (CheckMate 914): a double-blind, randomised, phase 3 trial","year":2023,"lang":"en","type":"article","venue":"The Lancet","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":172,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Cancer Institute; EMD Serono; Ono Pharmaceutical; Eisai; Incyte; Exelixis; Memorial Sloan-Kettering Cancer Center; Pfizer; Genentech; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Nivolumab; Renal cell carcinoma; Ipilimumab; Nephrectomy; Adjuvant; Placebo; Internal medicine; Urology; Clinical trial; Carcinoma; Oncology; Surgery; Gastroenterology; Immunotherapy; Kidney; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002092327,0.002519931,0.004681131,0.0004472679,0.0005033845,0.001610797,0.001438478,0.002607134,0.00938306],"category_scores_gemma":[0.002043165,0.00109665,0.003448776,0.000465404,0.001605368,0.001351261,0.0005634293,0.004911729,0.001802657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001231758,"about_ca_system_score_gemma":0.001250429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002282421,"about_ca_topic_score_gemma":0.0044682,"domain_scores_codex":[0.999191,0.0004121924,0.00004275705,0.0001603178,0.00005389264,0.0001399444],"domain_scores_gemma":[0.9990879,0.0003171166,0.0002007034,0.00008495044,0.00005076378,0.0002585877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9889157,0.001498399,0.00009640856,0.0006877946,0.0009041915,0.00001557278,0.00002627983,0.000184518,0.0008453538,0.00007784608,0.0005968066,0.006151107],"study_design_scores_gemma":[0.9821422,0.01643518,0.0003583901,0.0000315936,0.0003636403,0.00001214292,0.000009228917,0.0001715902,0.0001031192,0.0001012237,0.0002602272,0.00001135851],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675077,0.01606498,0.001608476,0.001555841,0.002494827,0.0044391,0.002056261,0.0004015075,0.003871409],"genre_scores_gemma":[0.9741756,0.00598808,0.002252816,0.002159582,0.0008793282,0.004407834,0.001320465,0.00007249392,0.00874381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00938306,"threshold_uncertainty_score":0.03138942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09256596557415632,"score_gpt":0.3391126640744914,"score_spread":0.2465466985003351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}