{"id":"W4319724957","doi":"10.1101/2023.02.08.527763","title":"Proteome-wide comparison of tertiary protein structures reveal extensive molecular mimicry in <i>Plasmodium</i> -human interactions","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Malaria Research and Control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; University of Calgary","keywords":"Plasmodium falciparum; Molecular mimicry; Proteome; Protein tertiary structure; Computational biology; Biology; Mimicry; Human proteome project; Plasmodium (life cycle); Proteomics; Parasite hosting; Malaria; Immune system; Bioinformatics; Genetics; Biochemistry; Gene; Computer science; Immunology; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002891088,0.000231022,0.0002803125,0.0003359488,0.0002301325,0.000366546,0.00009972365,0.000263747,0.001277966],"category_scores_gemma":[0.0003650472,0.0001252422,0.0002515412,0.0004248419,0.0001722158,0.0001890731,0.0002182664,0.0002894157,0.0003338649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001557306,"about_ca_system_score_gemma":0.00009685229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005315332,"about_ca_topic_score_gemma":0.0006580768,"domain_scores_codex":[0.999891,0.00002352151,0.00000790351,0.00004035658,0.00002039648,0.00001678919],"domain_scores_gemma":[0.9998623,0.00003899961,0.00004394782,0.00001605708,0.00001650365,0.00002221351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001718645,0.00007933938,0.06776948,0.0003706395,0.0002194183,0.0007915577,0.0002608889,0.001850256,0.9064724,0.0005586217,0.002980781,0.0169279],"study_design_scores_gemma":[0.00005567401,0.0004958963,0.6758991,0.00005837565,0.0002448643,0.005413208,0.0005559807,0.02044716,0.2824377,0.001194177,0.0131572,0.00004058855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952277,0.0005720054,0.001853844,0.00009986597,0.000008210885,0.000006276111,0.001687062,0.00007497577,0.0004700797],"genre_scores_gemma":[0.9945175,0.0001979311,0.002705037,0.00003964546,0.000005598592,0.000004938479,0.002327371,0.00001529487,0.0001865592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001277966,"threshold_uncertainty_score":0.004275203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02228856449345725,"score_gpt":0.2884078910274455,"score_spread":0.2661193265339882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}