{"id":"W4319751152","doi":"10.3390/curroncol30020164","title":"Lysine-Specific Demethylase 1 (LSD1)-Mediated Epigenetic Modification of Immunogenicity and Immunomodulatory Effects in Breast Cancers","year":2023,"lang":"en","type":"review","venue":"Current Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Epigenetics; Immune system; Medicine; Demethylase; Immunotherapy; Cancer research; Tumor microenvironment; Cancer; Epigenetic therapy; Breast cancer; Immune checkpoint; Carcinogenesis; Immunogenicity; Vorinostat; Immunology; Histone; Biology; Histone deacetylase; DNA methylation; Internal medicine; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000260451,0.0005252438,0.0006258782,0.001300977,0.0002021038,0.0005257066,0.0004824561,0.0006657112,0.002410488],"category_scores_gemma":[0.0002738561,0.0001857367,0.0002830175,0.0010453,0.0002882127,0.0006981645,0.0004498128,0.001082103,0.001328509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004536581,"about_ca_system_score_gemma":0.0005829748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006717379,"about_ca_topic_score_gemma":0.001396643,"domain_scores_codex":[0.9999279,0.00001246654,0.000009640657,0.00001372038,0.00002675689,0.000009545759],"domain_scores_gemma":[0.9999199,0.00003098186,0.0000139028,0.000002869574,0.00002158829,0.0000107401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007847967,0.00006230412,0.0001816928,0.01063337,0.00006608639,0.0002832076,0.00004850811,0.0004416741,0.005126016,0.003799269,0.02688712,0.9523922],"study_design_scores_gemma":[0.00001538099,0.0001008497,0.000897923,0.001351653,0.00007126384,0.00217666,0.00003907179,0.0001366335,0.00163591,0.001633661,0.9919252,0.00001591296],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002249563,0.9980977,0.0001714288,0.0001878618,0.0001495142,0.00000342527,0.00001431776,0.000008903084,0.001141797],"genre_scores_gemma":[0.001380004,0.997171,0.0001965553,0.0001574905,0.0001244151,0.000005163817,0.00002929622,0.00000164654,0.000934525],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002410488,"threshold_uncertainty_score":0.008063912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1043281720047787,"score_gpt":0.4031478796864308,"score_spread":0.2988197076816521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}