{"id":"W4319755433","doi":"10.1101/2023.02.08.527742","title":"Maturation of Nucleus Accumbens Synaptic Transmission Signals a Critical Period for the Rescue of Social Deficits in a Mouse Model of Autism Spectrum Disorder","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"University of Toronto Scarborough; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Institute of Human Development, Child and Youth Health; Hospital for Sick Children; University of Toronto","keywords":"Nucleus accumbens; Autism spectrum disorder; Excitatory postsynaptic potential; Neuroscience; Inhibitory postsynaptic potential; Neurotransmission; Neurodevelopmental disorder; Autism; Psychology; Period (music); Medicine; Developmental psychology; Central nervous system; Internal medicine; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002332808,0.0006078569,0.0004797781,0.0008985227,0.0003447666,0.0004436964,0.0005991271,0.0008259274,0.002612824],"category_scores_gemma":[0.0002695326,0.0003211058,0.0005358226,0.000203914,0.000609541,0.0005324881,0.0004426067,0.001950559,0.0008576245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006872575,"about_ca_system_score_gemma":0.0004560295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002314984,"about_ca_topic_score_gemma":0.005939084,"domain_scores_codex":[0.9995796,0.00003203415,0.00005849107,0.0001087687,0.0001318266,0.00008932486],"domain_scores_gemma":[0.9993181,0.00003274743,0.0002645525,0.00004590556,0.00006897565,0.0002696453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002298068,0.00006736119,0.0002435863,0.00002170107,0.000004894422,0.00008710264,0.00002771023,0.0000325585,0.9986474,0.00005804894,0.00003866237,0.0005412642],"study_design_scores_gemma":[0.0001011643,0.001981832,0.02893833,0.00005115364,0.0000411932,0.0009377528,0.0003518239,0.001562483,0.9633019,0.0002046633,0.002500965,0.00002676773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938974,0.0006645301,0.002053372,0.0002524843,0.00007772198,0.00006461642,0.001623681,0.0002454686,0.001120701],"genre_scores_gemma":[0.9857444,0.0006533805,0.003753534,0.0001484507,0.00001767362,0.0002173359,0.0009870828,0.0001718016,0.008306449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002612824,"threshold_uncertainty_score":0.008740783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04652159058649533,"score_gpt":0.2971794459567396,"score_spread":0.2506578553702443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}