{"id":"W4319764005","doi":"10.3390/molecules28041634","title":"Peptidic Inhibitors and a Fluorescent Probe for the Selective Inhibition and Labelling of Factor XIIIa Transglutaminase","year":2023,"lang":"en","type":"article","venue":"Molecules","topic":"Blood properties and coagulation","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Factor XIIIa; Tissue transglutaminase; Chemistry; Biochemistry; Proteases; Linker; Labelling; Fluorescence; Biophysics; Combinatorial chemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007446802,0.0000680391,0.0001061887,0.00004613403,0.00007887102,0.000009671548,0.00001126332,0.00003861938,0.000001875138],"category_scores_gemma":[0.0000271816,0.00004383327,0.0000285296,0.0001192429,0.00005624152,0.00002716965,0.00001186613,0.00005020078,5.517191e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007722036,"about_ca_system_score_gemma":0.00001739402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002986248,"about_ca_topic_score_gemma":0.00001175036,"domain_scores_codex":[0.9995668,0.00001394211,0.0001126974,0.0001191977,0.00008841317,0.00009893265],"domain_scores_gemma":[0.9997793,0.00004562712,0.00003184618,0.00005633416,0.00005651171,0.00003037727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004283487,0.00008172901,0.005172757,0.0007188449,0.0001020588,0.000005419368,0.005771616,0.00002624934,0.9276675,0.0003797949,0.0002978776,0.05934782],"study_design_scores_gemma":[0.002128902,0.0008663182,0.09548719,0.0003816505,0.0002285755,0.00001549061,0.001124453,0.01129126,0.8873135,0.0005653396,0.0004579223,0.0001393665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952533,0.001123151,0.001874485,0.001051625,0.00002244213,0.0006203383,0.00001354068,0.00002892097,0.00001219997],"genre_scores_gemma":[0.9993171,0.00020212,0.000258239,0.0000610198,0.0000389848,0.00004762895,0.00001311941,0.00001216418,0.00004963491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09031443,"threshold_uncertainty_score":0.1787469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02182506418808773,"score_gpt":0.2502521140403961,"score_spread":0.2284270498523084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}