{"id":"W4319764005","doi":"10.3390/molecules28041634","title":"Peptidic Inhibitors and a Fluorescent Probe for the Selective Inhibition and Labelling of Factor XIIIa Transglutaminase","year":2023,"lang":"en","type":"article","venue":"Molecules","topic":"Blood properties and coagulation","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Factor XIIIa; Tissue transglutaminase; Chemistry; Biochemistry; Proteases; Linker; Labelling; Fluorescence; Biophysics; Combinatorial chemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004209262,0.0006207239,0.0003433288,0.0002789978,0.0001905157,0.0003356647,0.0004131394,0.0007835201,0.001083374],"category_scores_gemma":[0.0002379854,0.0002985163,0.0003690291,0.0002740724,0.0003146455,0.0004394004,0.0003353784,0.0009174148,0.000491411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005439602,"about_ca_system_score_gemma":0.000241796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004750129,"about_ca_topic_score_gemma":0.0007507636,"domain_scores_codex":[0.9997004,0.00007643849,0.00001851045,0.00007614709,0.0000720009,0.00005655335],"domain_scores_gemma":[0.9998772,0.00002098098,0.00004903528,0.00001257775,0.0000142151,0.00002598459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008217443,0.00003233668,0.00004245967,0.00009278785,0.000007612046,0.00009167536,0.00002214819,0.0003186951,0.9944381,0.0005760895,0.0001061352,0.004189961],"study_design_scores_gemma":[0.00002770864,0.0005726929,0.0002714482,0.00001003641,0.00001527437,0.000276568,0.000008163192,0.0007662678,0.9925553,0.00004901626,0.005436822,0.0000106843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8306125,0.02492059,0.1278174,0.001038274,0.000181019,0.0005603074,0.0007186791,0.0005709398,0.01358036],"genre_scores_gemma":[0.9016067,0.00788707,0.08110815,0.000420164,0.00005160705,0.000371659,0.000632974,0.00005900926,0.007862659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001083374,"threshold_uncertainty_score":0.003946781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02182506418808773,"score_gpt":0.2502521140403961,"score_spread":0.2284270498523084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}