{"id":"W4319773746","doi":"10.1016/j.biopsych.2023.01.028","title":"Impact of Copy Number Variants and Polygenic Risk Scores on Psychopathology in the UK Biobank","year":2023,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Mental Health","keywords":"Anxiety; Mood; Psychopathology; Copy-number variation; Mood disorders; Psychiatry; Population; Medicine; Clinical psychology; Psychology; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000289727,0.0001319389,0.0001446183,0.00004209446,0.0000665916,0.00001063482,0.0001894909,0.0001892525,0.00007165065],"category_scores_gemma":[0.00005718505,0.00007523283,0.0001114774,0.0001762315,0.0001242085,0.000001531929,0.00005887766,0.0001096972,0.00003603297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000528155,"about_ca_system_score_gemma":0.00004162976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009910546,"about_ca_topic_score_gemma":0.00004400855,"domain_scores_codex":[0.9990516,0.000186593,0.0002147491,0.0002707721,0.00005595176,0.0002202829],"domain_scores_gemma":[0.9995589,0.00003665854,0.00008941325,0.000264135,0.00001685764,0.00003403381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000171126,0.00009699331,0.9910962,0.000003963011,0.00002968337,0.000001598168,0.00005283178,0.00001710422,0.004777111,0.001405592,0.002134127,0.0002136657],"study_design_scores_gemma":[0.0004751477,0.0008489628,0.9946857,0.000006591366,0.000007563777,0.00002813286,0.0001383398,0.00000427327,0.0001155378,0.003430552,0.0001561299,0.000103039],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982795,0.0002875698,0.00001468716,0.0001911531,0.0002547893,0.0001286965,0.0001440537,0.000009772398,0.0006897775],"genre_scores_gemma":[0.9986336,0.0006886427,0.0001766833,0.0001951057,0.0001658208,0.00001692867,0.0000784729,0.000006556877,0.00003819103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004661574,"threshold_uncertainty_score":0.3067906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01598701045784161,"score_gpt":0.2944573456539927,"score_spread":0.2784703351961511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}