{"id":"W4319786039","doi":"10.1016/j.bbagen.2023.130319","title":"SS148 and WZ16 inhibit the activities of nsp10-nsp16 complexes from all seven human pathogenic coronaviruses","year":2023,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - General Subjects","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Structural Genomics Consortium","funders":"Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; McGill University; Genentech; Bayer; National Institute of Allergy and Infectious Diseases; Pfizer; Bristol-Myers Squibb","keywords":"Coronavirus disease 2019 (COVID-19); Coronavirus; Biology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Pandemic; Virology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001529444,0.0004765747,0.0002344345,0.0001652856,0.00008133925,0.0001964947,0.0001964992,0.0002055608,0.001402449],"category_scores_gemma":[0.0001138571,0.0001284392,0.0002688112,0.0001199341,0.0001311963,0.0002024197,0.0002049606,0.0004349418,0.0004374497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001441925,"about_ca_system_score_gemma":0.0001971333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000301309,"about_ca_topic_score_gemma":0.0006024612,"domain_scores_codex":[0.9998926,0.00001832281,0.00001931806,0.00001440549,0.00003270459,0.00002264817],"domain_scores_gemma":[0.9999574,0.000006344333,0.00001263644,0.000006072568,0.000007425273,0.00001008393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002760292,0.00007088292,0.000300616,0.00007781447,0.00001354123,0.0000254822,0.000008631355,0.0001200084,0.994217,0.00007685175,0.00009317704,0.004720008],"study_design_scores_gemma":[0.00006268037,0.001032356,0.002681549,0.000009450884,0.00002052007,0.0002308772,0.00001375642,0.0005978707,0.9913028,0.00003866796,0.004004515,0.000004912536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875895,0.005456107,0.003623261,0.0001337752,0.00006166811,0.0001019608,0.000573569,0.00008943185,0.002370762],"genre_scores_gemma":[0.9817878,0.004959502,0.005707288,0.0001016271,0.00002091924,0.0001243942,0.001843501,0.00002712746,0.005427749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001402449,"threshold_uncertainty_score":0.004691601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05662975195918573,"score_gpt":0.3395988722684469,"score_spread":0.2829691203092611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}