{"id":"W4319812103","doi":"10.1056/nejmoa2213614","title":"Ide-cel or Standard Regimens in Relapsed and Refractory Multiple Myeloma","year":2023,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":705,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"Celgene; Bristol-Myers Squibb","keywords":"Multiple myeloma; Refractory (planetary science); Medicine; Oncology; Internal medicine; Lenalidomide; Materials science; Metallurgy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007420029,0.0001989546,0.0009133723,0.0002209564,0.0001494786,0.0002586409,0.000206379,0.0003087396,0.002211471],"category_scores_gemma":[0.0006965376,0.0001366079,0.000437935,0.0001837946,0.0002323942,0.00025279,0.0001809974,0.0005588956,0.0002816837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001972093,"about_ca_system_score_gemma":0.0002551808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000147084,"about_ca_topic_score_gemma":0.0004610952,"domain_scores_codex":[0.999824,0.00007623157,0.00001421407,0.00002771278,0.00002661704,0.00003133366],"domain_scores_gemma":[0.9996847,0.0001121842,0.00006789564,0.00002821773,0.000008386196,0.00009865972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5477128,0.009558047,0.02646869,0.0006748788,0.000862721,0.0004867297,0.0001690275,0.002058195,0.02523604,0.0004941365,0.005194988,0.3810837],"study_design_scores_gemma":[0.2563072,0.5034445,0.2039045,0.0002968027,0.00134174,0.002424939,0.0001845734,0.0058793,0.009324622,0.001862975,0.0149617,0.00006722614],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958742,0.002530214,0.0001541916,0.0001474131,0.00005716184,0.00009062539,0.0001199255,0.00002232391,0.00100401],"genre_scores_gemma":[0.9971078,0.001443549,0.00028012,0.0002641539,0.00008371678,0.0001014626,0.0002315916,0.000004626055,0.0004830748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002211471,"threshold_uncertainty_score":0.007398129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0453368430261291,"score_gpt":0.3410931074954077,"score_spread":0.2957562644692786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}