{"id":"W4319823697","doi":"10.1177/10915818231153996","title":"An Overview of Gene Editing Modalities and Related Non-clinical Testing Considerations","year":2023,"lang":"en","type":"review","venue":"International Journal of Toxicology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"","keywords":"Genetic enhancement; Gene delivery; Computational biology; Genome editing; Modalities; Medicine; Preclinical testing; Bioinformatics; Biology; Gene; CRISPR; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001016245,0.001029453,0.001310293,0.003906595,0.0003967005,0.001322519,0.001013826,0.00155263,0.00484955],"category_scores_gemma":[0.001132742,0.0004202644,0.0008225612,0.002392671,0.0006824353,0.001690057,0.0005617196,0.002490766,0.002595791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007899695,"about_ca_system_score_gemma":0.001200697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009821736,"about_ca_topic_score_gemma":0.001462445,"domain_scores_codex":[0.9995711,0.00007240381,0.00006951515,0.00007216171,0.000181235,0.00003353358],"domain_scores_gemma":[0.9991574,0.0005340405,0.00008580005,0.0000221703,0.0001579465,0.00004271674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007408433,0.0001631235,0.0001860667,0.01673931,0.00005069115,0.0004253326,0.00007387831,0.0004465765,0.003564105,0.005849202,0.02292684,0.9495008],"study_design_scores_gemma":[0.00001235952,0.000183903,0.0005631489,0.003214254,0.00006900913,0.002936183,0.00005409259,0.0001544494,0.001472516,0.002332291,0.9889819,0.00002578772],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001939723,0.9959693,0.0005459722,0.0003311915,0.0002525815,0.00001898313,0.00003835246,0.00001740492,0.002632231],"genre_scores_gemma":[0.0009984251,0.996394,0.0007177908,0.0003465641,0.0002531983,0.00003233725,0.00006122088,0.000004382644,0.001192086],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00484955,"threshold_uncertainty_score":0.01622337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2665457715366977,"score_gpt":0.5064597054411514,"score_spread":0.2399139339044537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}