{"id":"W4319823697","doi":"10.1177/10915818231153996","title":"An Overview of Gene Editing Modalities and Related Non-clinical Testing Considerations","year":2023,"lang":"en","type":"review","venue":"International Journal of Toxicology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"","keywords":"Genetic enhancement; Gene delivery; Computational biology; Genome editing; Modalities; Medicine; Preclinical testing; Bioinformatics; Biology; Gene; CRISPR; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001502927,0.000186828,0.0008414446,0.0002767014,0.00004423906,0.00003500868,0.0004293174,0.0003961416,0.00006338563],"category_scores_gemma":[0.001805873,0.0001653795,0.0003101097,0.00009608504,0.0002152342,0.00001055188,0.0001418432,0.0004310983,0.000005286991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003777603,"about_ca_system_score_gemma":0.0008485906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005461549,"about_ca_topic_score_gemma":0.0000286908,"domain_scores_codex":[0.9973266,0.0005322436,0.00143945,0.0002438465,0.0002866508,0.000171204],"domain_scores_gemma":[0.9971687,0.0005537817,0.001146517,0.0001950634,0.0008268938,0.0001090267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007148594,0.0008721395,0.0005701291,0.003516663,0.01052303,0.001079059,0.0002528534,0.0004705723,0.04464609,0.0006879334,0.003610547,0.9330561],"study_design_scores_gemma":[0.01572061,0.0783908,0.001708808,0.04296513,0.004981788,0.03994917,0.0009815223,0.00162613,0.03063132,0.01724141,0.7616284,0.004174839],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01698248,0.9810559,0.00002729629,0.0001772543,0.001295316,0.0002021031,0.0001096554,0.000006045202,0.0001439367],"genre_scores_gemma":[0.004139953,0.9931851,0.0009596618,0.00009801026,0.001376661,0.000009892534,0.00007884379,0.00004365241,0.0001081993],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9288813,"threshold_uncertainty_score":0.674398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2665457715366977,"score_gpt":0.5064597054411514,"score_spread":0.2399139339044537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}