{"id":"W4319826957","doi":"10.1021/acs.jnatprod.2c01027","title":"Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase","year":2023,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science; Hokkaido University; University of Tokyo; Japan Agency for Medical Research and Development; Japan Science and Technology Agency; Nihon University","keywords":"Chalcone; Flavanone; Chalcone synthase; Chalcone isomerase; Biochemistry; Isomerase; Thioesterase; Docking (animal); Enzyme; Stereochemistry; Biosynthesis; Chemistry; Biology; Flavonoid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001326689,0.000348814,0.0002592326,0.0004296721,0.0001307125,0.0003705317,0.0001803644,0.0002490029,0.001306793],"category_scores_gemma":[0.0002369807,0.00009271437,0.000321895,0.0003742456,0.0001262277,0.000221567,0.000125433,0.0002938198,0.001117715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002514974,"about_ca_system_score_gemma":0.0002738974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001204345,"about_ca_topic_score_gemma":0.001207764,"domain_scores_codex":[0.9998964,0.000009720414,0.000009621994,0.00002830074,0.00003457177,0.00002135258],"domain_scores_gemma":[0.9998832,0.00002529398,0.00001668744,0.00001449464,0.00002509781,0.00003520116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004118895,0.0000160455,0.0003331502,0.0000189961,0.000003043802,0.00007483827,0.000009946949,0.00004016795,0.9977168,0.000065389,0.00003164434,0.001648832],"study_design_scores_gemma":[0.00001246664,0.00009838238,0.03405123,0.000007207765,0.00002611277,0.0008927741,0.0000676592,0.002606765,0.9573618,0.0002091614,0.004655312,0.00001106307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.96784,0.002205717,0.01933472,0.0003355526,0.00003400848,0.00007692604,0.006309348,0.0002396544,0.003624073],"genre_scores_gemma":[0.9590991,0.001188582,0.01607538,0.0001194489,0.00002258509,0.00005235928,0.01673205,0.00006345233,0.006647017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001306793,"threshold_uncertainty_score":0.004371703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101310941176512,"score_gpt":0.2187073561903432,"score_spread":0.2076942467785781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}