{"id":"W4319827670","doi":"10.1038/s41467-023-35932-3","title":"Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Center for Advanced Study, University of Illinois at Urbana-Champaign; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institute on Alcohol Abuse and Alcoholism; Natural Sciences and Engineering Research Council of Canada; National Human Genome Research Institute; National Institute of Biomedical Imaging and Bioengineering; University of Illinois at Urbana-Champaign; National Science Foundation; U.S. Department of Health and Human Services; National Institutes of Health; American Cancer Society","keywords":"Biology; Transcriptome; RNA splicing; Splicing factor; Alternative splicing; Genome instability; Cell biology; RNA-binding protein; Cancer research; DNA damage; Gene expression; RNA; Gene; Genetics; Messenger RNA; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003418225,0.00008110685,0.00007545816,0.00008462021,0.0002071598,0.00002725269,0.0007099999,0.0001990564,0.000002910086],"category_scores_gemma":[0.0001300477,0.00006061304,0.00003683273,0.0002825427,0.0000927568,0.000004143378,0.0003326736,0.0005140904,0.00001414666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001005308,"about_ca_system_score_gemma":0.00004244848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004041515,"about_ca_topic_score_gemma":0.0005101494,"domain_scores_codex":[0.9991965,0.0001972638,0.0001113965,0.0001756549,0.00009858521,0.0002206434],"domain_scores_gemma":[0.9988294,0.0001387399,0.0000314994,0.0009200099,0.00004228126,0.00003809537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003220083,0.0001677341,0.03088775,0.00003364099,0.00001527271,0.000035641,0.001491235,0.00002380367,0.9515294,0.002439628,0.007145438,0.006198269],"study_design_scores_gemma":[0.002723146,0.0007062309,0.6946281,0.00007152788,0.00005198863,0.0002266138,0.00498198,0.00620693,0.03520928,0.0004827772,0.2537113,0.001000238],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861592,0.01045761,0.00003108183,0.001073238,0.00003133231,0.0001855306,0.00001474684,0.00001356546,0.002033659],"genre_scores_gemma":[0.9912424,0.007136108,0.0004533503,0.000497652,0.00002054365,0.00002601404,0.00009450481,0.000009173829,0.0005202208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9163201,"threshold_uncertainty_score":0.2471728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02886025377956283,"score_gpt":0.3177848902508087,"score_spread":0.2889246364712459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}