{"id":"W4319827670","doi":"10.1038/s41467-023-35932-3","title":"Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Center for Advanced Study, University of Illinois at Urbana-Champaign; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institute on Alcohol Abuse and Alcoholism; Natural Sciences and Engineering Research Council of Canada; National Human Genome Research Institute; National Institute of Biomedical Imaging and Bioengineering; University of Illinois at Urbana-Champaign; National Science Foundation; U.S. Department of Health and Human Services; National Institutes of Health; American Cancer Society","keywords":"Biology; Transcriptome; RNA splicing; Splicing factor; Alternative splicing; Genome instability; Cell biology; RNA-binding protein; Cancer research; DNA damage; Gene expression; RNA; Gene; Genetics; Messenger RNA; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001559001,0.0004560385,0.0003551372,0.0002775206,0.0001193098,0.0001818478,0.0001318429,0.0002968523,0.001472384],"category_scores_gemma":[0.0001159428,0.0001690548,0.0002461535,0.0001518712,0.0003168864,0.0001449504,0.0001765169,0.0004013675,0.0004572797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002186036,"about_ca_system_score_gemma":0.0001643535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003355798,"about_ca_topic_score_gemma":0.0009408296,"domain_scores_codex":[0.9998091,0.000044333,0.00002361966,0.00003634332,0.00005420316,0.00003237428],"domain_scores_gemma":[0.9998455,0.00002048276,0.00005717946,0.00001983372,0.000008898742,0.00004802854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009945924,0.000006703009,0.0002323742,0.00001695586,0.000004876953,0.0001394645,0.000005719598,0.00002309877,0.9989472,0.00004779225,0.00002260888,0.0004538711],"study_design_scores_gemma":[0.00001428453,0.0002895199,0.008193704,0.000005913696,0.00001494336,0.0009477266,0.00004275961,0.000489226,0.9887031,0.0001084881,0.00118518,0.000005037825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944584,0.001095617,0.002658586,0.0001335413,0.00003868761,0.0000174258,0.0004123257,0.0002170643,0.0009683697],"genre_scores_gemma":[0.9957997,0.0005971618,0.001244059,0.00004528967,0.000008323077,0.00002590998,0.000478666,0.00003175907,0.001769113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001472384,"threshold_uncertainty_score":0.004925609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02886025377956283,"score_gpt":0.3177848902508087,"score_spread":0.2889246364712459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}