{"id":"W4319827996","doi":"10.1002/anse.202300001","title":"Comparative Characterization of Diverse DNA Aptamers for Recognition of Spike Proteins of Multiple SARS‐CoV‐2 Variants","year":2023,"lang":"en","type":"article","venue":"Analysis & Sensing","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Aptamer; DNA; Target protein; Computational biology; Epitope; Biology; Plasma protein binding; Molecular biology; Chemistry; Genetics; Biochemistry; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002145781,0.0001168145,0.0004334619,0.0002940509,0.00004579949,0.000004498333,0.00005686798,0.00009532445,7.077382e-7],"category_scores_gemma":[0.0001035465,0.0001109933,0.0003060311,0.0008926955,0.0001058774,0.000007517607,0.00004041873,0.00002998876,4.756448e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007768609,"about_ca_system_score_gemma":0.00002048395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006524108,"about_ca_topic_score_gemma":0.0001376192,"domain_scores_codex":[0.9990346,0.00006766693,0.0003921879,0.0002528691,0.0001240415,0.0001286118],"domain_scores_gemma":[0.9987756,0.00002823074,0.0005163709,0.0002271304,0.0004338386,0.00001883717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000109343,0.00004290834,0.0006925346,0.00002985292,0.0007967455,4.934813e-7,0.0001042087,0.00002394247,0.992685,0.000001453304,0.00001497058,0.005498564],"study_design_scores_gemma":[0.0002271375,0.0001326333,0.003831675,0.00003686018,0.0008066127,5.028938e-7,0.0002485095,0.01055486,0.9839635,0.00003028034,0.00005335219,0.0001140777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750602,0.000004512269,0.02445061,0.00001829755,0.00001668623,0.0002180797,0.0001919827,0.00001672034,0.00002286343],"genre_scores_gemma":[0.9882506,0.00005442656,0.009801237,0.00001695554,0.00002859878,0.000001910592,0.001815358,0.000009210234,0.00002167416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01464938,"threshold_uncertainty_score":0.4526174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04254400261386833,"score_gpt":0.3117140682637013,"score_spread":0.269170065649833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}