{"id":"W4319864378","doi":"10.5267/j.ccl.2023.1.004","title":"Synthesis of phthalimide and naphthalimide derived Biginelli compounds and evaluation of their anti-inflammatory and anti-oxidant activities","year":2023,"lang":"en","type":"article","venue":"Current Chemistry Letters","topic":"Multicomponent Synthesis of Heterocycles","field":"Chemistry","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemistry; Phthalic anhydride; Thiourea; Phthalimide; Organic chemistry; Antioxidant; Biginelli reaction; Catalysis; Urea; Ethanol; Medicinal chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001449895,0.0003298167,0.0002162832,0.0002143741,0.0001104732,0.0001037939,0.0002723376,0.0002304087,0.001696853],"category_scores_gemma":[0.00009869014,0.00009628633,0.0001759896,0.0001966223,0.0001018888,0.0002654638,0.0001365821,0.0003172933,0.0003940265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001722641,"about_ca_system_score_gemma":0.0002073945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001611854,"about_ca_topic_score_gemma":0.0006971217,"domain_scores_codex":[0.9999396,0.000007336459,0.000005608705,0.00001379431,0.00001983286,0.00001386134],"domain_scores_gemma":[0.9999384,0.000006739719,0.00001427807,0.00000777998,0.00001576364,0.00001709388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008600432,0.00007600806,0.00009808756,0.0002225039,0.00001058068,0.0001134781,0.00002375288,0.0002987432,0.9891961,0.000383524,0.00009657993,0.009394784],"study_design_scores_gemma":[0.00002452299,0.001215883,0.001161323,0.00001111814,0.00001719132,0.0002561806,0.00001513129,0.000407571,0.9913162,0.0000909759,0.005473074,0.00001080884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9598276,0.009021991,0.01857675,0.000181793,0.00008809417,0.000437025,0.001026349,0.0001163562,0.01072408],"genre_scores_gemma":[0.9618393,0.00675347,0.02239335,0.0001161119,0.00003078767,0.0002166928,0.001043661,0.00002582339,0.007580787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001696853,"threshold_uncertainty_score":0.005676568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03814153689237387,"score_gpt":0.2749865812704458,"score_spread":0.236845044378072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}