{"id":"W4319864383","doi":"10.5267/j.ccl.2022.11.006","title":"Synthesis of novel 2, 5-disubstituted tetrazole derivatives as potent biological agents","year":2023,"lang":"en","type":"article","venue":"Current Chemistry Letters","topic":"Synthesis of Tetrazole Derivatives","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Kuvempu University","keywords":"Chemistry; DNA gyrase; Piperidine; Phenacyl; ADME; Tetrazole; Biphenyl; Stereochemistry; Morpholine; Docking (animal); Carboxylic acid; Combinatorial chemistry; Organic chemistry; Biochemistry; In vitro; Escherichia coli","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001554068,0.00044734,0.000510573,0.00009263254,0.0001234966,0.00003842884,0.0008273001,0.0001846919,0.001209561],"category_scores_gemma":[0.001474817,0.0004253198,0.0003115196,0.000487059,0.0005117772,0.0001323525,0.000257786,0.0003445,0.0001317581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001064873,"about_ca_system_score_gemma":0.00005130591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006839864,"about_ca_topic_score_gemma":9.903803e-8,"domain_scores_codex":[0.9975545,0.00001957494,0.0005985236,0.0006916753,0.0005229415,0.0006127356],"domain_scores_gemma":[0.9982124,0.0005482382,0.0003302545,0.0006367451,0.00007489808,0.000197449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003833657,0.0003661937,0.005152101,0.0005058621,0.0001554542,0.00002057482,0.0001456994,0.0000854368,0.9865299,0.00001829638,0.001306956,0.005675163],"study_design_scores_gemma":[0.0004946885,0.000001570096,0.006793152,0.000398443,0.00003980997,0.00001200812,0.0003630419,0.0002228374,0.9894944,0.00002178785,0.001698593,0.0004596419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959908,0.0001779096,0.00008807999,0.0008985929,0.0002002841,0.00008775669,0.0001847905,0.0004282774,0.001943471],"genre_scores_gemma":[0.9989458,0.0001726041,0.0002501282,0.00004241132,0.0002170724,0.0001082868,0.0001845681,0.00004778782,0.00003138755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005215521,"threshold_uncertainty_score":0.9998199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06108507748518567,"score_gpt":0.2973284158907402,"score_spread":0.2362433384055546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}