{"id":"W4319864386","doi":"10.5267/j.ccl.2022.12.006","title":"Synthesis and anti-inflammatory activity of S-oxides of pyridinyloxy substituted imidazo[2,1-b][1,3]thiazines","year":2023,"lang":"en","type":"article","venue":"Current Chemistry Letters","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Diastereomer; Chemistry; Diclofenac Sodium; Anti-inflammatory; In vivo; Sulfoxide; Stereochemistry; Proton NMR; Carrageenan; Sulfur; Medicinal chemistry; Organic chemistry; Chromatography; Pharmacology; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007864543,0.0003107657,0.0001487681,0.0001759449,0.0001063966,0.0000969643,0.0001821824,0.000141052,0.001036364],"category_scores_gemma":[0.00006839195,0.0001149225,0.0001618539,0.0001515133,0.0001214425,0.0001613561,0.000096936,0.0002666083,0.0002139483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001197568,"about_ca_system_score_gemma":0.0002412399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003183809,"about_ca_topic_score_gemma":0.0009654712,"domain_scores_codex":[0.9999641,0.00000525342,0.000003928174,0.000006186312,0.00001049166,0.00001001833],"domain_scores_gemma":[0.9999633,0.0000028877,0.00001500253,0.000003733342,0.000008011756,0.000007139857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009986446,0.0000296225,0.0001109597,0.0001558913,0.00000834497,0.0001320935,0.00003465967,0.0002678947,0.9956388,0.0003183377,0.00008848513,0.003115131],"study_design_scores_gemma":[0.00003129868,0.0008803829,0.001758554,0.00001236739,0.00002342254,0.0002355854,0.00002665679,0.0006918886,0.991316,0.00007385608,0.00494141,0.000008605701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823518,0.004459362,0.006820069,0.0001609383,0.00005531016,0.000106237,0.0005140638,0.00008842678,0.005443874],"genre_scores_gemma":[0.9839183,0.004550984,0.007573423,0.00005164281,0.00002611735,0.0000606843,0.0003972647,0.00001481083,0.003406764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001036364,"threshold_uncertainty_score":0.003467023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01894508633223597,"score_gpt":0.2419874238266636,"score_spread":0.2230423374944276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}