{"id":"W4319869868","doi":"10.1101/2023.02.10.528032","title":"SARS-COV-2 NSP5 Antagonizes MHC II Expresion by Subverting Histone Deacetylase 2","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Canadian Institutes of Health Research","keywords":"CIITA; Ectopic expression; Biology; Antigen processing; Gene knockdown; Antigen presentation; Cell biology; Antigen; Immune system; Histone deacetylase 2; MHC class I; Major histocompatibility complex; MHC class II; Immunology; T cell; Histone deacetylase; Histone; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001205619,0.0003047873,0.0001867868,0.0001109546,0.0001191816,0.0002343286,0.0001959488,0.0002118181,0.001728604],"category_scores_gemma":[0.00006702286,0.0001132459,0.000341601,0.00005400599,0.0001954017,0.0001629611,0.0001678953,0.0005741062,0.0004012484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002460315,"about_ca_system_score_gemma":0.0001779855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005515087,"about_ca_topic_score_gemma":0.0009029807,"domain_scores_codex":[0.999881,0.00001741112,0.00001444462,0.00001886116,0.00003189892,0.0000362746],"domain_scores_gemma":[0.9999491,0.000005687675,0.00001570636,0.000008372405,0.000006352211,0.00001475697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007049987,0.00002676777,0.000108523,0.00002680348,0.000003770512,0.00002813721,0.000005474627,0.00003872835,0.9989103,0.00007603752,0.00004266799,0.0006622111],"study_design_scores_gemma":[0.00002254039,0.0003818111,0.003967448,0.000006709859,0.00000937088,0.0001951187,0.00003290466,0.001104015,0.9913982,0.00003333822,0.002844942,0.000003532608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924787,0.001572811,0.002124378,0.0001704933,0.00007789503,0.00003568771,0.0002975677,0.00007339549,0.003169016],"genre_scores_gemma":[0.9937165,0.0007584337,0.001263476,0.00008659433,0.00001403622,0.00002348497,0.0004283369,0.00001193251,0.003697312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001728604,"threshold_uncertainty_score":0.005782723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0431699365663533,"score_gpt":0.3175479904094586,"score_spread":0.2743780538431053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}