{"id":"W4319915108","doi":"10.1016/j.omto.2023.02.003","title":"Targeting carcinoembryonic antigen-expressing tumors using a novel transcriptional and translational dual-regulated oncolytic herpes simplex virus type 1","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada)","funders":"College of Medicine, University of Florida","keywords":"Oncolytic virus; Herpes simplex virus; Immune system; Virus; Cancer research; Biology; Viral replication; Carcinoembryonic antigen; Immunotherapy; Virology; Immunology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000620354,0.0004174637,0.000361825,0.0002325939,0.0003671934,0.0001221718,0.0002630353,0.0002943627,0.00007725607],"category_scores_gemma":[0.00005059579,0.0004417945,0.0001826066,0.000715923,0.0002427705,0.00002002538,0.00007688651,0.0002304894,0.00001479509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005988049,"about_ca_system_score_gemma":0.0006246421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004483205,"about_ca_topic_score_gemma":0.00003196749,"domain_scores_codex":[0.9972159,0.0001942647,0.0004971495,0.0007223681,0.0006303639,0.0007399804],"domain_scores_gemma":[0.9989384,0.00004630892,0.0001337249,0.0004173739,0.0002474387,0.0002167129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001386424,0.0001619027,0.0002639657,0.00002894161,0.000225877,0.0000428457,0.0002428063,0.01752658,0.9745961,0.00006079174,0.00008069466,0.005383104],"study_design_scores_gemma":[0.004598434,0.001632971,0.003409289,0.00008315347,0.0000473274,0.00007343211,0.0001717453,0.06432566,0.9078786,0.0003888691,0.01647888,0.0009116777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990598,0.003926232,0.00421821,0.0002859199,0.0001396106,0.0005958952,0.00008710074,0.00008795298,0.00006111945],"genre_scores_gemma":[0.9954394,0.0009291677,0.002085255,0.0004643341,0.000259323,0.00002395391,0.0004759291,0.0001503191,0.0001723769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06671751,"threshold_uncertainty_score":0.9998034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04717215919280651,"score_gpt":0.3268019723086337,"score_spread":0.2796298131158272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}