{"id":"W4319917306","doi":"10.1016/j.bpj.2022.11.1533","title":"Substrate stiffness regulates focal adhesion kinase alternative splicing in breast cancer","year":2023,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Focal adhesion; Adhesion; Alternative splicing; Breast cancer; Substrate (aquarium); RNA splicing; Stiffness; Cell biology; Cancer research; Chemistry; Materials science; Biology; Cancer; Biochemistry; Signal transduction; Exon; Genetics; Composite material; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002000037,0.0001320568,0.0001584933,0.0002228872,0.0002424764,0.0004567816,0.0001722722,0.0002856437,0.002289971],"category_scores_gemma":[0.0003448384,0.0001820631,0.0002164611,0.0001506241,0.0002037131,0.0001972834,0.0002433537,0.0004783011,0.0006030619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002855239,"about_ca_system_score_gemma":0.0001586716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005859369,"about_ca_topic_score_gemma":0.001161949,"domain_scores_codex":[0.9998141,0.00003115231,0.00001587324,0.00003126946,0.00005880675,0.00004890585],"domain_scores_gemma":[0.9997876,0.00005220739,0.00006148812,0.00002742144,0.00002844528,0.00004280409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002467749,0.00002099785,0.001473346,0.0000132506,0.000006792784,0.0001585769,0.00003244308,0.00007037883,0.9963151,0.0002147114,0.00006590051,0.001381783],"study_design_scores_gemma":[0.00006113105,0.0003466105,0.1285869,0.000009959906,0.00003492069,0.00162141,0.0003166502,0.003474862,0.8628436,0.000551028,0.002130433,0.00002243755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980557,0.0004659891,0.0006284619,0.0001038179,0.00001967114,0.00000413248,0.00008957858,0.00001670268,0.0006161006],"genre_scores_gemma":[0.9986754,0.0001436886,0.0002035804,0.00002883446,0.00000470636,0.000004477651,0.000101133,0.000009707887,0.0008283759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002289971,"threshold_uncertainty_score":0.007660747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03096376819064377,"score_gpt":0.3336536146308812,"score_spread":0.3026898464402374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}