{"id":"W4319926779","doi":"10.1016/j.bpj.2022.11.298","title":"Development of IKs activating compounds for treatment of long QT syndrome","year":2023,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Long QT syndrome; Chemistry; Pharmacology; Internal medicine; Cardiology; Medicine; QT interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003399265,0.0005514449,0.0006141122,0.0004274262,0.0002413359,0.0005163126,0.0004506222,0.0005429129,0.00334725],"category_scores_gemma":[0.0002232149,0.0001387688,0.0005154049,0.0002167364,0.0002708427,0.0003996571,0.0002404617,0.001842399,0.0008378277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002426704,"about_ca_system_score_gemma":0.0003253127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003254436,"about_ca_topic_score_gemma":0.0007255318,"domain_scores_codex":[0.9999156,0.00001895111,0.00000973382,0.00001566846,0.00001530422,0.00002468538],"domain_scores_gemma":[0.999922,0.00002142493,0.00001951335,0.00000353157,0.00001349723,0.00002001883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005305001,0.001396224,0.0008128828,0.002159948,0.0002537109,0.001667259,0.0002309753,0.001092906,0.5815962,0.007308309,0.006481151,0.3916955],"study_design_scores_gemma":[0.01906599,0.06016015,0.02015238,0.001784592,0.001413945,0.01334249,0.0005301622,0.007112774,0.4992343,0.008128192,0.3688183,0.0002566471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4836987,0.4297178,0.02932934,0.006709623,0.002706337,0.0008624541,0.001111635,0.00110366,0.04476041],"genre_scores_gemma":[0.7818507,0.1920779,0.01258498,0.002315232,0.0007746983,0.000337428,0.0009832318,0.00008304654,0.008992778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00334725,"threshold_uncertainty_score":0.01119769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03183872713109746,"score_gpt":0.3071631852382883,"score_spread":0.2753244581071908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}