{"id":"W4319936455","doi":"10.1016/j.bpj.2022.11.1082","title":"Mutant cancer protein STAT5b has two distinct conformational states","year":2023,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University; University of Toronto","funders":"","keywords":"Antiparallel (mathematics); Dimer; Mutant; Molecular dynamics; Point mutation; Phosphorylation; Chemistry; Biology; Biophysics; Gene; Biochemistry; Physics; Computational chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001890526,0.0001133782,0.0001348908,0.00005548625,0.0003384637,0.0002591174,0.000138671,0.00002885968,0.001435641],"category_scores_gemma":[0.00002941433,0.00007949804,0.00006454397,0.0002000594,0.0001187632,0.0003075482,0.0000412702,0.0001777918,0.000663214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005849721,"about_ca_system_score_gemma":0.0001190767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006211117,"about_ca_topic_score_gemma":0.00001349459,"domain_scores_codex":[0.9988922,0.00004479147,0.0002439843,0.000130406,0.0004016627,0.0002869653],"domain_scores_gemma":[0.9995041,0.00003547967,0.0001333899,0.00008599065,0.0001113719,0.0001296641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005535306,0.00001676363,0.00006550433,0.0000107741,0.000009247731,0.00002084714,0.0001705017,0.0002782187,0.9926088,0.00128559,0.003956918,0.001521489],"study_design_scores_gemma":[0.001109761,0.0002086436,0.009580315,0.00007597822,0.00002770745,0.00007781576,0.000197063,0.00513953,0.954682,0.00966746,0.01889886,0.0003348879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996622,0.000007467429,0.001152175,0.0008214653,0.0007662857,0.000101706,0.0001175642,0.0000910287,0.0003202546],"genre_scores_gemma":[0.9982141,0.000007488979,0.0001918235,0.0001013017,0.00113984,0.00001801213,0.00002705436,0.00001082728,0.0002895603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03792682,"threshold_uncertainty_score":0.9994772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.022604697716042,"score_gpt":0.2778827260881783,"score_spread":0.2552780283721363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}