{"id":"W4319936653","doi":"10.1016/j.bpj.2022.11.371","title":"A new tool for producing and investigating recombinant sarcomeric actin","year":2023,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"","keywords":"Actin; Cell biology; Myosin; Biology; Tropomyosin; Gene knockin; Transgene; Actin remodeling; Recombinant DNA; Fusion protein; Mutant; Cytoskeleton; Gene; Genetics; Actin cytoskeleton; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001285336,0.0008224569,0.0005728078,0.00140776,0.0006337412,0.0008462145,0.0009598127,0.001025147,0.001956315],"category_scores_gemma":[0.000872516,0.0005239579,0.0006858939,0.0005905911,0.0006577658,0.0008793435,0.0008637432,0.002312011,0.001317788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003306101,"about_ca_system_score_gemma":0.0003240729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003422478,"about_ca_topic_score_gemma":0.0005907614,"domain_scores_codex":[0.999469,0.0001439862,0.00005621846,0.0001218884,0.0001474458,0.00006137627],"domain_scores_gemma":[0.9987615,0.0005857883,0.0001504462,0.0002842819,0.00008481617,0.0001331534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003721861,0.0000320208,0.00006484747,0.00004592143,0.000008187727,0.0000856913,0.00004831314,0.00003459155,0.9958261,0.0006741573,0.0001173834,0.00302552],"study_design_scores_gemma":[0.00005793199,0.0002858161,0.001045427,0.00004130708,0.00006922318,0.001183527,0.00004980665,0.001216933,0.9728319,0.000721658,0.02247389,0.00002247524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3312004,0.006844813,0.6464422,0.00157328,0.0006774361,0.0006234024,0.00159437,0.001292041,0.009752044],"genre_scores_gemma":[0.4766834,0.006859099,0.4953181,0.0006382765,0.0002754741,0.001049056,0.00514526,0.0008469211,0.01318439],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.001956315,"threshold_uncertainty_score":0.006797552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03968943336803822,"score_gpt":0.3056577700606363,"score_spread":0.2659683366925981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}