{"id":"W4319936814","doi":"10.1016/j.bpj.2022.11.725","title":"A de novo arrhythmogenic Nav1.5 variant, E171Q, causes multiple biophysical defects","year":2023,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiovascular Effects of Exercise","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; Simon Fraser University","funders":"","keywords":"NAV1; Computational biology; Biology; Chemistry; Sodium channel","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005000171,0.0003701622,0.0008172083,0.0002941482,0.0002570598,0.0001490612,0.0002240795,0.0001986259,0.00008437717],"category_scores_gemma":[0.0007267555,0.0003089196,0.001425519,0.0009898386,0.0001793723,0.0001761364,0.0001591977,0.000871687,0.001642848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002390022,"about_ca_system_score_gemma":0.000306518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002580922,"about_ca_topic_score_gemma":0.000003144286,"domain_scores_codex":[0.9971743,0.0001868981,0.0003833831,0.0004662577,0.0008565084,0.0009327017],"domain_scores_gemma":[0.9978952,0.0003672781,0.0001192536,0.0005946021,0.0001862965,0.0008373918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005431926,0.0004212808,0.001487902,0.000106694,0.0006142289,0.01527789,0.0001344448,0.0001253025,0.9730987,0.0002056288,0.003821235,0.004163476],"study_design_scores_gemma":[0.02394055,0.003125333,0.3758259,0.001609189,0.004036583,0.06839444,0.0003006459,0.02136616,0.4783088,0.001226293,0.01940434,0.002461803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969612,0.0001087122,0.0006841077,0.000595794,0.0005866014,0.0003969822,0.00001971754,0.0003262064,0.0003206734],"genre_scores_gemma":[0.9942358,0.0001398995,0.0006123028,0.0003859967,0.004150352,0.00003186444,0.00002158943,0.00009871216,0.0003234603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.49479,"threshold_uncertainty_score":0.9999363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01556510096497469,"score_gpt":0.2688919118139295,"score_spread":0.2533268108489548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}