{"id":"W4319937611","doi":"10.1101/2023.02.09.527935","title":"A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Irving Medical Center, Columbia University; UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill; Francis Crick Institute; Gillings School of Public Health; University of Oxford; School of Medicine, University of North Carolina at Chapel Hill; University of North Carolina at Chapel Hill; Ohio State University","keywords":"GSK-3; Kinase; Neuroprotection; Small molecule; Endoplasmic reticulum; Biology; Cell biology; Cyclin-dependent kinase; Biochemistry; Chemistry; Neuroscience; Cell; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000130027,0.0004837377,0.0002242397,0.0002336847,0.0001756362,0.0001384607,0.000247384,0.00029097,0.00304807],"category_scores_gemma":[0.00008156496,0.0001123486,0.0002394619,0.0001597505,0.0001551205,0.000191042,0.0001479686,0.0004047661,0.0004123995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002605156,"about_ca_system_score_gemma":0.0002014666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004192636,"about_ca_topic_score_gemma":0.0008149807,"domain_scores_codex":[0.9999262,0.00001306026,0.000004489575,0.00001731821,0.00001736347,0.00002148061],"domain_scores_gemma":[0.9999664,0.000006927326,0.000007864022,0.000004513366,0.000005355938,0.000008890978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001722179,0.00006808393,0.00006949135,0.0001021944,0.0000119701,0.00007380291,0.00001076839,0.0002431,0.996265,0.0002230654,0.0001827497,0.002577537],"study_design_scores_gemma":[0.00006199986,0.001088341,0.0005118634,0.000007621376,0.00001685129,0.0001459771,0.000008040846,0.0004165055,0.9947534,0.0000513602,0.002931477,0.000006599432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737278,0.004786581,0.009715098,0.0002833424,0.0001037837,0.0001984454,0.0008122871,0.0002379451,0.01013471],"genre_scores_gemma":[0.9891306,0.001462613,0.004359383,0.0001662511,0.00001789208,0.0000846907,0.0005882657,0.00001965863,0.004170595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00304807,"threshold_uncertainty_score":0.01019681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131179988329019,"score_gpt":0.2085068878086701,"score_spread":0.1971950879253799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}