{"id":"W4319937663","doi":"10.1016/j.bpj.2022.11.678","title":"Nuclear stiffness regulates cellular senescence via YAP dependent mechanotransduction","year":2023,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Progeria; Lamin; Mechanotransduction; Nuclear lamina; Cell biology; Senescence; Biology; Telomerase; Premature aging; Cell nucleus; LMNA; Nuclear localization sequence; Chemistry; Nuclear protein; Genetics; Nucleus; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001810416,0.0003158419,0.0001531537,0.0002086731,0.0003149708,0.0005130928,0.0002027046,0.0003160049,0.002206305],"category_scores_gemma":[0.0002244023,0.0001869219,0.0002682863,0.0001087838,0.0003521118,0.0005818135,0.000522083,0.0006385822,0.0004227869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004356906,"about_ca_system_score_gemma":0.0001994906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003910746,"about_ca_topic_score_gemma":0.0009204859,"domain_scores_codex":[0.999878,0.00001673092,0.000008680277,0.00002137052,0.00002665735,0.00004843031],"domain_scores_gemma":[0.9997887,0.00002801917,0.00007087628,0.00002194724,0.0000313977,0.00005914496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001610459,0.00001245092,0.000332501,0.00001886247,0.000003122852,0.00005091702,0.00002015635,0.00004230781,0.9983456,0.0002586305,0.00004118402,0.0007132584],"study_design_scores_gemma":[0.00003852421,0.0002485751,0.0439966,0.000013152,0.00002273104,0.0003330944,0.0002081714,0.002756145,0.9496866,0.0006027914,0.002076553,0.00001696703],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927948,0.001377777,0.003377416,0.0003223798,0.00004147553,0.00001470082,0.0002163105,0.00008770862,0.001767415],"genre_scores_gemma":[0.9974837,0.0003121323,0.0003654816,0.00003814587,0.000008086049,0.00001618661,0.0001145515,0.00001220941,0.001649506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002206305,"threshold_uncertainty_score":0.007380784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007073456466246584,"score_gpt":0.2111446773585048,"score_spread":0.2040712208922582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}