{"id":"W4319937663","doi":"10.1016/j.bpj.2022.11.678","title":"Nuclear stiffness regulates cellular senescence via YAP dependent mechanotransduction","year":2023,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Progeria; Lamin; Mechanotransduction; Nuclear lamina; Cell biology; Senescence; Biology; Telomerase; Premature aging; Cell nucleus; LMNA; Nuclear localization sequence; Chemistry; Nuclear protein; Genetics; Nucleus; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009566417,0.0001294549,0.0001057534,0.00004831572,0.000201158,0.00005508154,0.0001409949,0.0001269171,0.00006069106],"category_scores_gemma":[0.00001095123,0.0001126742,0.0001238249,0.0001534586,0.00004758332,0.000009479528,0.000049868,0.0001658084,0.0001478574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001498177,"about_ca_system_score_gemma":0.00001698639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003941089,"about_ca_topic_score_gemma":8.057467e-7,"domain_scores_codex":[0.9991258,0.00004579733,0.0001520116,0.000236259,0.000207616,0.0002325184],"domain_scores_gemma":[0.9995711,0.000003584248,0.00006664946,0.0001773403,0.00007031432,0.0001110018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001078327,0.00002615631,0.00001940922,0.000007193527,0.0000330321,0.00001995706,0.00003303154,0.00005609009,0.9903743,0.0001156788,0.001007982,0.008199286],"study_design_scores_gemma":[0.0003900309,0.0002172526,0.002977982,0.00001154826,0.00003358669,0.0001815625,0.00007662772,0.0008648729,0.9852629,0.0005545709,0.009213391,0.0002157083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937447,0.00001683935,0.004907201,0.0002406238,0.0009233581,0.00005871156,0.000003687511,0.00004334464,0.00006149669],"genre_scores_gemma":[0.9977028,0.00007275217,0.0001552708,0.00008625289,0.001657679,0.00000132507,0.00003240485,0.0000299737,0.0002614778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008205408,"threshold_uncertainty_score":0.4594719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007073456466246584,"score_gpt":0.2111446773585048,"score_spread":0.2040712208922582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}