{"id":"W4319939125","doi":"10.21203/rs.3.rs-2494605/v1","title":"Intramolecular Hydroamidation of Alkenes Enabling Asymmetric Synthesis of β-Lactams via Unprecedented Mechanism of NiH Catalysis","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kootenay Association for Science & Technology","funders":"Institute for Basic Science","keywords":"Intramolecular force; Mechanism (biology); Catalysis; Chemistry; Combinatorial chemistry; Enantioselective synthesis; Stereochemistry; Organic chemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002251019,0.0004099133,0.0001681842,0.0001525019,0.00009776172,0.0002814794,0.0002348161,0.0001977978,0.001760181],"category_scores_gemma":[0.0001735278,0.0001269751,0.0001716034,0.00009520143,0.0003293624,0.0004553539,0.0005151225,0.0005140653,0.0005629272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002062405,"about_ca_system_score_gemma":0.0002265352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002220818,"about_ca_topic_score_gemma":0.0003276983,"domain_scores_codex":[0.999868,0.00001823367,0.00001080568,0.00002786384,0.00002951725,0.00004549839],"domain_scores_gemma":[0.9999484,0.000008551048,0.00001442209,0.00001106738,0.000007625606,0.000009978091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001611303,0.000113231,0.0004828734,0.0003506771,0.00002294935,0.0009540968,0.000174635,0.001090878,0.9629281,0.01328,0.0008642359,0.01957716],"study_design_scores_gemma":[0.00004272507,0.0002847278,0.0005573944,0.0000137065,0.00001055096,0.0006033171,0.00003654703,0.002445267,0.9838824,0.0008402815,0.01126721,0.00001579847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.915045,0.002266179,0.03974644,0.0004241396,0.0002025252,0.0001236039,0.0002756613,0.0004386373,0.04147768],"genre_scores_gemma":[0.990571,0.0008419526,0.005430697,0.00005015384,0.00002482118,0.00002566848,0.00007760197,0.00002389129,0.002954212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001760181,"threshold_uncertainty_score":0.005888402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05848916303529428,"score_gpt":0.3504955584377659,"score_spread":0.2920063954024716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}