{"id":"W4319943894","doi":"10.2139/ssrn.4335542","title":"Inhibition of Histone Deacetylase Activity Enables Embryonic and Trophoblast Stem Cells to Access Restricted Cell Fates and Self-Assemble into Blastocyst-Like Structures","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Blastocyst; Trophoblast; Embryonic stem cell; Cell biology; Histone deacetylase; Stem cell; Histone; Chemistry; Embryo; Andrology; Biology; Embryogenesis; Pregnancy; Genetics; Medicine; Fetus; Biochemistry; Placenta; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001808131,0.0004513029,0.000367751,0.000184473,0.0001214742,0.0005134959,0.0003019546,0.0002855,0.002797637],"category_scores_gemma":[0.000149436,0.0002395655,0.0003604593,0.0001797592,0.0003023403,0.0001535697,0.000315851,0.0007766518,0.0008596862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003962345,"about_ca_system_score_gemma":0.0003090936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001533451,"about_ca_topic_score_gemma":0.00278736,"domain_scores_codex":[0.9998097,0.00001584037,0.00001833883,0.00006484631,0.00004485698,0.00004649067],"domain_scores_gemma":[0.9998803,0.00003042229,0.00003309853,0.00002137889,0.000008557417,0.00002617942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001365787,0.00002087853,0.0001677017,0.0000318842,0.00001155651,0.00002332689,0.00001030845,0.00007407638,0.9975001,0.0002517299,0.00006782206,0.001704036],"study_design_scores_gemma":[0.00001741533,0.00008712585,0.001001327,0.000001938502,0.00001353545,0.00005907493,0.000008291241,0.0007688084,0.9955648,0.00005523097,0.002419824,0.00000267137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656583,0.003398319,0.01714312,0.0003286846,0.0002728668,0.00007875123,0.001493479,0.0005201886,0.01110637],"genre_scores_gemma":[0.9882527,0.0009510569,0.003271427,0.00008907961,0.00001960537,0.00002879014,0.0008988013,0.00009605017,0.006392515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002797637,"threshold_uncertainty_score":0.009359002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229096116899441,"score_gpt":0.2830354753479237,"score_spread":0.2707445141789293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}