{"id":"W4319966429","doi":"10.3390/biomedicines11020505","title":"Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials","year":2023,"lang":"en","type":"review","venue":"Biomedicines","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Disease; Medicine; Clinical trial; Spinocerebellar ataxia; Movement disorders; Amyotrophic lateral sclerosis; Therapeutic approach; Huntington's disease; Bioinformatics; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004022635,0.000451967,0.002289535,0.0003121114,0.00004135445,0.00003143673,0.0006608147,0.000719493,0.00004344826],"category_scores_gemma":[0.0002155775,0.0003061261,0.0007343558,0.0004210807,0.0002019008,0.000002150254,0.0003748435,0.0003311443,0.0001825526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000356011,"about_ca_system_score_gemma":0.0003448847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002010232,"about_ca_topic_score_gemma":0.0002720843,"domain_scores_codex":[0.9946869,0.001793962,0.00179528,0.0008902866,0.0003892973,0.0004442726],"domain_scores_gemma":[0.9977238,0.0007967661,0.0005310662,0.0007517888,0.00004026644,0.0001562687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002648,0.000169945,0.00008097608,0.002917566,0.0004100332,0.00001693007,0.00002458399,1.230375e-7,0.0005533824,0.000003140867,0.01264102,0.9831558],"study_design_scores_gemma":[0.0008015801,0.0002190066,0.00006254567,0.00315232,0.0002066322,3.801332e-7,0.0001428337,0.000002421615,0.00006435312,0.0000833997,0.9949578,0.0003067262],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003136989,0.9963436,0.00004203509,0.0004676514,0.0009455527,0.001286171,0.0003823878,0.00002663986,0.0001922615],"genre_scores_gemma":[0.0000489681,0.9931039,0.00003660606,0.0001027459,0.00143759,0.0002636938,0.001396561,0.00009127249,0.003518716],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9828491,"threshold_uncertainty_score":0.9999391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2833875904547534,"score_gpt":0.5014122172364177,"score_spread":0.2180246267816643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}