{"id":"W4319973481","doi":"10.3390/cells12040560","title":"Harnessing Innate Immunity to Treat Mycobacterium tuberculosis Infections: Heat-Killed Caulobacter crescentus as a Novel Biotherapeutic","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mitacs; University of British Columbia; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Mycobacterium tuberculosis; Innate immune system; Tuberculosis; Immunology; Immunity; Biology; Population; Immune system; Microbiology; Virology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002148976,0.0002909173,0.0003149298,0.0004560993,0.0004672989,0.00009554574,0.0001648246,0.0002954318,0.003503802],"category_scores_gemma":[0.00005930874,0.0002671516,0.0001841812,0.0007349345,0.00008427777,0.0002265322,0.0001207305,0.000418353,0.01847898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001761705,"about_ca_system_score_gemma":0.00005748278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001068163,"about_ca_topic_score_gemma":0.00002378661,"domain_scores_codex":[0.9984542,0.0002029223,0.0003808908,0.0003845923,0.00004893115,0.0005285275],"domain_scores_gemma":[0.9991703,0.000133961,0.00007222325,0.0004531045,0.0001166953,0.00005368548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002409567,0.0002767712,0.0003793134,0.00003394782,0.0001420872,0.00000268333,0.0006868542,0.00002979282,0.9849985,0.0000205603,0.01137359,0.00181498],"study_design_scores_gemma":[0.001314762,0.0002688304,0.007417492,0.00009475068,0.00007445872,0.00006370086,0.0004028101,0.00002289691,0.686003,0.00000788196,0.3040126,0.0003168344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841188,0.0004442769,0.0001944772,0.0007209566,0.009293051,0.0004288138,0.00001720956,0.0004771884,0.004305224],"genre_scores_gemma":[0.9500884,0.0004200586,0.00001706533,0.001570238,0.00008410997,0.00007148792,0.0002919014,0.00005352419,0.04740314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2989954,"threshold_uncertainty_score":0.9999781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01600238499471524,"score_gpt":0.2596953819927755,"score_spread":0.2436929969980603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}