{"id":"W4319978914","doi":"10.1093/bjd/ljac057","title":"Efficacy of downtitration or treatment withdrawal compared with continuous dosing after successful treatment with baricitinib in patients with moderate-to-severe atopic dermatitis in a randomized substudy from the long-term extension study BREEZE-AD3","year":2022,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"Eli Lilly and Company","keywords":"Dosing; Medicine; Placebo; Atopic dermatitis; Cohort; Internal medicine; Anesthesia; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005970929,0.001126903,0.00299097,0.0003737589,0.0005287142,0.0009433411,0.0007422981,0.001367902,0.002397089],"category_scores_gemma":[0.003528319,0.0004757146,0.004402352,0.0004407237,0.0005991754,0.0008399984,0.0004723929,0.002466061,0.0004560507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008373572,"about_ca_system_score_gemma":0.0007343416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009263195,"about_ca_topic_score_gemma":0.003095441,"domain_scores_codex":[0.9978234,0.00131377,0.0002380418,0.0002687333,0.0001658314,0.0001903173],"domain_scores_gemma":[0.9968953,0.000974544,0.001117905,0.0003239652,0.0002331365,0.0004550287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.945398,0.004943502,0.01261947,0.001104914,0.007103787,0.00005850887,0.0001439592,0.0004338469,0.004764431,0.00004186632,0.0006969909,0.02269073],"study_design_scores_gemma":[0.6132842,0.2728053,0.09500188,0.0002156782,0.01270036,0.0002585748,0.0001223001,0.001270185,0.002220128,0.0001912949,0.001859722,0.00007032825],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892051,0.006895215,0.0003356473,0.0002231586,0.0001604811,0.00145884,0.0007729992,0.00003765848,0.0009109043],"genre_scores_gemma":[0.9951598,0.001304963,0.0004085808,0.0002942762,0.0001493011,0.001306872,0.0008162783,0.000008418127,0.0005514355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005970929,"threshold_uncertainty_score":0.03157765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009185506710510306,"score_gpt":0.2455962267584434,"score_spread":0.2364107200479331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}