{"id":"W4319983072","doi":"10.3390/ijms24043547","title":"Increased Expression of Hepatic Stearoyl-CoA Desaturase (SCD)-1 and Depletion of Eicosapentaenoic Acid (EPA) Content following Cytotoxic Cancer Therapy Are Reversed by Dietary Fish Oil","year":2023,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Technology Futures","keywords":"Eicosapentaenoic acid; Fish oil; Docosahexaenoic acid; FADS2; Lipid metabolism; Endocrinology; Internal medicine; Biology; Polyunsaturated fatty acid; Fatty acid metabolism; Fatty acid; Biochemistry; Metabolism; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000725042,0.0002929008,0.0002366558,0.0003484315,0.0001147205,0.000155725,0.00007867911,0.0001897717,0.001007831],"category_scores_gemma":[0.00009607658,0.0001497213,0.0001755898,0.000192279,0.0002174789,0.0001664195,0.0001083884,0.0003295153,0.0001501121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002935292,"about_ca_system_score_gemma":0.0002236577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008007254,"about_ca_topic_score_gemma":0.001449388,"domain_scores_codex":[0.9999104,0.000008988718,0.000006710426,0.00002397387,0.0000220718,0.00002789395],"domain_scores_gemma":[0.9998788,0.00001104276,0.00005074421,0.0000105812,0.00001432956,0.00003452797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005565068,0.00001794526,0.0007197621,0.00001231873,0.00000334413,0.00002896891,0.000007917545,0.00001469395,0.9979538,0.00001136453,0.000006777094,0.0006665785],"study_design_scores_gemma":[0.00002309428,0.0009031474,0.0198517,0.000003982561,0.00002212643,0.0001546334,0.00004076805,0.0001694268,0.9781707,0.00002111379,0.0006358225,0.00000342516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986191,0.0005092932,0.0003893153,0.00003194533,0.000007477066,0.00000995471,0.0001555525,0.00001983298,0.0002575183],"genre_scores_gemma":[0.9964629,0.0006682451,0.0006509432,0.00002613014,0.000004540685,0.00003142526,0.0003967195,0.000008171807,0.001750958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001007831,"threshold_uncertainty_score":0.003371537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03662673095013558,"score_gpt":0.3087579271261195,"score_spread":0.2721311961759839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}