{"id":"W4319983800","doi":"10.1186/s13075-023-02997-w","title":"Interferon and interferon-induced cytokines as markers of impending clinical progression in ANA+ individuals without a systemic autoimmune rheumatic disease diagnosis","year":2023,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Princess Margaret Cancer Centre; Toronto Western Hospital; Arthritis Society; Mount Sinai Hospital; St. Michael's Hospital; SickKids Foundation; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Arthritis Society; Pfizer","keywords":"Medicine; Rheumatology; Asymptomatic; Immunology; Interferon; Antibody; Biomarker; Internal medicine; Disease; Cytokine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.007490939,0.000326183,0.001162433,0.001533016,0.0001684895,0.0001051959,0.000514586,0.0002526413,0.000154726],"category_scores_gemma":[0.002930642,0.0002663955,0.000228623,0.001837439,0.0005354622,0.0002585272,0.0007003853,0.0009990871,0.00009048358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002851173,"about_ca_system_score_gemma":0.0005865979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003032581,"about_ca_topic_score_gemma":0.0001022002,"domain_scores_codex":[0.9924199,0.00228372,0.00148609,0.0008254901,0.001911893,0.001072906],"domain_scores_gemma":[0.996409,0.001491696,0.0002477751,0.0009742744,0.0002942256,0.0005830346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002709644,0.0003583551,0.8522236,0.001209263,0.000154602,0.0002152501,0.001930538,4.739213e-7,0.01174418,0.00003585177,0.0005101601,0.1289081],"study_design_scores_gemma":[0.02366776,0.008784762,0.8311378,0.117261,0.0000270603,0.001697202,0.008390302,0.001373811,0.005817839,0.0007840651,0.0004056399,0.0006526718],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866766,0.008034856,0.000001694602,0.0009936303,0.0002649913,0.003697353,0.00002485909,0.0001319884,0.0001740337],"genre_scores_gemma":[0.9592896,0.03911193,0.00005333341,0.00002735334,0.00007089877,0.001089008,0.00002730319,0.00009687809,0.0002337707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1282555,"threshold_uncertainty_score":0.9999788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.100667066873293,"score_gpt":0.4446730902826271,"score_spread":0.3440060234093341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}