{"id":"W4319993017","doi":"10.32920/21982910.v1","title":"Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate Akt signaling","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research, Innovation and Science; Canada Research Chairs","keywords":"FYN; Cell biology; Protein kinase B; Clathrin; Phosphorylation; Endocytosis; Signal transduction; Proto-oncogene tyrosine-protein kinase Src; Epidermal growth factor; PI3K/AKT/mTOR pathway; Signal transducing adaptor protein; Biology; Cancer research; Epidermal growth factor receptor; Chemistry; Receptor; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001427678,0.0003171409,0.0001963913,0.000305774,0.0004387796,0.0004667513,0.0001854497,0.0004126531,0.00236981],"category_scores_gemma":[0.000129239,0.0002185444,0.0002577085,0.0001423978,0.00022109,0.0003081958,0.000352977,0.0004684071,0.001122603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008273319,"about_ca_system_score_gemma":0.0003609954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001129022,"about_ca_topic_score_gemma":0.001405594,"domain_scores_codex":[0.9998522,0.000008330101,0.000006084066,0.00003050441,0.00003755643,0.00006530853],"domain_scores_gemma":[0.9999459,0.000003101463,0.0000144264,0.000004236967,0.000008399529,0.0000239755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002880969,0.00002087391,0.0009851438,0.00007235343,0.00000922019,0.0001535865,0.00003918018,0.0001092984,0.9909124,0.001015811,0.0006157995,0.005778108],"study_design_scores_gemma":[0.00005900385,0.00007465533,0.03497231,0.00002030832,0.00001701656,0.0007930214,0.00007340284,0.003380565,0.9453713,0.0005564037,0.01466872,0.00001328082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816961,0.004647479,0.00561591,0.0004581638,0.0001010651,0.00003643582,0.0008638409,0.0001999692,0.006380931],"genre_scores_gemma":[0.9843051,0.001493849,0.003283806,0.00009838056,0.00002853383,0.0000536924,0.001287825,0.00005134165,0.009397487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00236981,"threshold_uncertainty_score":0.007927835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1333243047129349,"score_gpt":0.3751611061742844,"score_spread":0.2418368014613495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}