{"id":"W4319997932","doi":"10.1016/j.omtm.2023.01.003","title":"Persistent hematopoietic polyclonality after lentivirus-mediated gene therapy for Fabry disease","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Juravinski Hospital; Alberta Children's Hospital; Princess Margaret Cancer Centre; University of Calgary; Hôpital Fleurimont; Western University; University of Toronto; Université de Sherbrooke; McMaster University; Dalhousie University; Juravinski Cancer Centre; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; University Health Network; University of Alberta","funders":"Canadian Institutes of Health Research; Medizinischen Hochschule Hannover; Kidney Foundation of Canada; Midwest Athletes Against Childhood Cancer","keywords":"Genetic enhancement; Lentivirus; Dominance (genetics); Fabry disease; Biology; Gene; Immunology; Medicine; Disease; Genetics; Internal medicine; Viral disease; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008357689,0.0001666861,0.000419377,0.0002526666,0.0001866599,0.0003393802,0.0001481633,0.0002622761,0.0004370635],"category_scores_gemma":[0.0006658444,0.00007811632,0.0001641859,0.0001709486,0.0003783997,0.0001969586,0.0001909526,0.0004352611,0.00006596477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000241398,"about_ca_system_score_gemma":0.0002261703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004495686,"about_ca_topic_score_gemma":0.0004953808,"domain_scores_codex":[0.9997032,0.0001122248,0.00001651242,0.00004573265,0.00006787418,0.00005434747],"domain_scores_gemma":[0.9997392,0.0001348778,0.00003920616,0.00003808717,0.00001559818,0.0000330331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003132169,0.001339837,0.008701146,0.0001067502,0.00007681802,0.001251788,0.0003039805,0.001171222,0.8813264,0.0009976308,0.0002550689,0.1013372],"study_design_scores_gemma":[0.001616016,0.06432102,0.05034113,0.00003255584,0.0002377806,0.008118058,0.0001148546,0.007334823,0.8629414,0.0005200823,0.004393603,0.00002868347],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966151,0.0007130243,0.001671868,0.00003848321,0.000005590201,0.00005458229,0.00002378267,0.00003091202,0.0008467818],"genre_scores_gemma":[0.9990453,0.0001521373,0.0003910478,0.0000304061,0.000006236831,0.00001987576,0.00004127956,0.000007377031,0.0003063642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008357689,"threshold_uncertainty_score":0.004420042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1377495466456052,"score_gpt":0.468279797118913,"score_spread":0.3305302504733079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}