{"id":"W4319997932","doi":"10.1016/j.omtm.2023.01.003","title":"Persistent hematopoietic polyclonality after lentivirus-mediated gene therapy for Fabry disease","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Juravinski Hospital; Alberta Children's Hospital; Princess Margaret Cancer Centre; University of Calgary; Hôpital Fleurimont; Western University; University of Toronto; Université de Sherbrooke; McMaster University; Dalhousie University; Juravinski Cancer Centre; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; University Health Network; University of Alberta","funders":"Canadian Institutes of Health Research; Medizinischen Hochschule Hannover; Kidney Foundation of Canada; Midwest Athletes Against Childhood Cancer","keywords":"Genetic enhancement; Lentivirus; Dominance (genetics); Fabry disease; Biology; Gene; Immunology; Medicine; Disease; Genetics; Internal medicine; Viral disease; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005526757,0.0004807276,0.0009167819,0.0002486506,0.0001989409,0.00006502505,0.0003897946,0.0002883078,0.0004335509],"category_scores_gemma":[0.001286895,0.0003909253,0.001172135,0.0007865277,0.0002743734,0.00006365303,0.0001955116,0.0004729393,0.000297465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001741175,"about_ca_system_score_gemma":0.0008585834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009108557,"about_ca_topic_score_gemma":0.000001113736,"domain_scores_codex":[0.994159,0.001453173,0.001240143,0.001124538,0.001054373,0.0009687715],"domain_scores_gemma":[0.9965826,0.001132101,0.000171462,0.0008757351,0.0003451094,0.0008930048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01640127,0.003158418,0.05502493,0.0002978202,0.003094563,0.001074372,0.001339537,0.000007397041,0.03759935,0.00007032517,0.001104343,0.8808277],"study_design_scores_gemma":[0.02202457,0.001887056,0.6333075,0.0002476012,0.0002381837,0.00002522662,0.0003411739,0.001063426,0.06105496,0.003077415,0.2750444,0.001688526],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9122906,0.008794433,0.06996618,0.005187017,0.0004696561,0.002886546,0.00003389263,0.0002842387,0.0000873927],"genre_scores_gemma":[0.6831214,0.00708273,0.2857344,0.01474386,0.0003172664,0.004125134,0.0008192524,0.00034931,0.003706702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8791391,"threshold_uncertainty_score":0.9998543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1377495466456052,"score_gpt":0.468279797118913,"score_spread":0.3305302504733079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}