{"id":"W4320009175","doi":"10.1016/j.curtheres.2023.100694","title":"Cumulative Laxation Response with Methylnaltrexone: Implications for Hospitalized Patients with Advanced Illness and Opioid-Induced Constipation","year":2023,"lang":"en","type":"article","venue":"Current Therapeutic Research","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bausch Health; Progenics Pharmaceuticals","keywords":"Medicine; Constipation; Placebo; Opioid; Dosing; Randomized controlled trial; Adverse effect; Anesthesia; Laxative; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008447684,0.000464441,0.001229774,0.0004523234,0.0002413266,0.000778327,0.0003897916,0.0003815914,0.001412757],"category_scores_gemma":[0.01209078,0.0001470175,0.002820213,0.0007228533,0.0003264999,0.0006391595,0.0004914255,0.0006966704,0.00006848593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004449876,"about_ca_system_score_gemma":0.0007546098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007267693,"about_ca_topic_score_gemma":0.002126971,"domain_scores_codex":[0.9959203,0.002501755,0.0005678131,0.0003827883,0.0004798037,0.000147488],"domain_scores_gemma":[0.983954,0.009135973,0.005251198,0.0006535149,0.000543444,0.0004618855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04915471,0.0004647322,0.8795509,0.001067117,0.008992635,0.0002078493,0.000135475,0.001239968,0.002191481,0.0001347938,0.0004366232,0.05642376],"study_design_scores_gemma":[0.002254203,0.01126507,0.9758418,0.0001767304,0.005696647,0.0003764,0.0001540951,0.002554137,0.0007430547,0.0002042942,0.0007027754,0.00003089742],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883,0.008800531,0.0008302833,0.0003464811,0.00003052217,0.0001542386,0.0007109386,0.00001460926,0.0008124901],"genre_scores_gemma":[0.9981698,0.0006786339,0.0004724821,0.0001291588,0.0000488804,0.00005270046,0.0003798862,0.000002774833,0.00006564767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008447684,"threshold_uncertainty_score":0.04467618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1303003089224846,"score_gpt":0.4418576654047166,"score_spread":0.311557356482232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}