{"id":"W4320009175","doi":"10.1016/j.curtheres.2023.100694","title":"Cumulative Laxation Response with Methylnaltrexone: Implications for Hospitalized Patients with Advanced Illness and Opioid-Induced Constipation","year":2023,"lang":"en","type":"article","venue":"Current Therapeutic Research","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bausch Health; Progenics Pharmaceuticals","keywords":"Medicine; Constipation; Placebo; Opioid; Dosing; Randomized controlled trial; Adverse effect; Anesthesia; Laxative; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009852418,0.0001441863,0.000213274,0.0003128555,0.0003487562,0.00003900029,0.00007626752,0.00004214974,0.000009649902],"category_scores_gemma":[0.0008301628,0.0001024564,0.00003177549,0.0008963307,0.0002447604,0.0001425624,0.00003012338,0.0002310799,0.000008421859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008434703,"about_ca_system_score_gemma":0.0002548658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000970062,"about_ca_topic_score_gemma":0.000009003784,"domain_scores_codex":[0.9983411,0.000277619,0.0001984678,0.0003823291,0.0004292774,0.0003711701],"domain_scores_gemma":[0.9971948,0.001137541,0.00008590973,0.0002836435,0.001151163,0.0001469015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03775622,0.0007691542,0.6804511,0.0003880757,0.0001396107,0.000001278092,0.002105196,0.00005331983,0.00622628,0.001740244,0.0001215765,0.2702479],"study_design_scores_gemma":[0.005965479,0.002836791,0.9866369,0.0002312404,0.00005159077,0.000002452631,0.0005440578,0.000674483,0.0002887912,0.001923434,0.0007221767,0.0001226255],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909243,0.0001585528,0.00396067,0.001951712,0.00004059889,0.002806376,0.0000369552,0.0000854937,0.00003533252],"genre_scores_gemma":[0.9984001,0.00004446681,0.0004882048,0.00002832683,0.00001607373,0.0006987795,0.000249377,0.00002537623,0.00004929646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3061858,"threshold_uncertainty_score":0.417805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1303003089224846,"score_gpt":0.4418576654047166,"score_spread":0.311557356482232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}