{"id":"W4320011429","doi":"10.2139/ssrn.4330807","title":"CDK8 Inhibitors Antagonize HIV-1 Reactivation and Promote Provirus Latency in T Cells","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University; University of British Columbia","funders":"","keywords":"Provirus; Latency (audio); Virology; Human immunodeficiency virus (HIV); Medicine; Biology; Computer science; Genome; Gene; Genetics; Telecommunications","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001201121,0.0003903381,0.000324628,0.0002650824,0.0001634237,0.000401001,0.0003225386,0.0002651304,0.008347256],"category_scores_gemma":[0.0002722031,0.0001697893,0.0002609036,0.0001594817,0.0001639508,0.0002417075,0.0001944852,0.0008429002,0.001786137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000306808,"about_ca_system_score_gemma":0.0003196007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007406824,"about_ca_topic_score_gemma":0.001361627,"domain_scores_codex":[0.9998873,0.00001843139,0.000008079433,0.00001503126,0.00001910427,0.0000520073],"domain_scores_gemma":[0.9999171,0.00002666083,0.00001321155,0.00001420699,0.000009413236,0.00001926948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004788905,0.000646484,0.0007004128,0.0002631757,0.00006423568,0.0001823843,0.00004225571,0.001170911,0.9558476,0.001071276,0.002491649,0.03273064],"study_design_scores_gemma":[0.0003125956,0.001536269,0.003160953,0.0000143352,0.00004102388,0.0002997103,0.00004189433,0.001925182,0.9847091,0.0003151856,0.007635199,0.000008543896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777864,0.005142988,0.001598362,0.0003628733,0.0003228854,0.00006118818,0.001276081,0.0004095929,0.01303975],"genre_scores_gemma":[0.9891481,0.001876812,0.0008706594,0.00007084982,0.00005062003,0.00003853956,0.0007465081,0.00005926627,0.007138568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008347256,"threshold_uncertainty_score":0.0279243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01393067794058194,"score_gpt":0.2564619130203332,"score_spread":0.2425312350797513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}