{"id":"W4320015013","doi":"10.2139/ssrn.4318823","title":"&lt;i&gt;Staphylococcus aureus&lt;/i&gt;&amp;nbsp;Drives Itch and Scratch-Induced Skin Damage Through a V8 Protease-PAR1 Axis","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Staphylococcus aureus; Gene knockdown; Protease; Scratching; Microbiology; Virulence; Serine protease; Virulence factor; Biology; Pathogen; Proteases; Skin infection; Immunology; Bacteria; Gene; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002028678,0.0006911926,0.0005949867,0.0003870593,0.0003166747,0.001000583,0.0003515341,0.001066127,0.016068],"category_scores_gemma":[0.0002961058,0.0004082875,0.0006059784,0.0002732489,0.0004774869,0.0007155989,0.0004885873,0.002764626,0.01004841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005188845,"about_ca_system_score_gemma":0.000395934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009776889,"about_ca_topic_score_gemma":0.001029256,"domain_scores_codex":[0.9994585,0.00004402591,0.0000327331,0.0001438652,0.0001270391,0.0001938632],"domain_scores_gemma":[0.9997568,0.00003474363,0.00005191494,0.00003865013,0.00002177926,0.00009605638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005932705,0.00008044088,0.0002293023,0.0001143119,0.00001583024,0.0001170146,0.00002887513,0.00009845001,0.9934433,0.0004996241,0.001320866,0.00345875],"study_design_scores_gemma":[0.0001325962,0.0003959769,0.01494891,0.00003488432,0.00002347787,0.000341315,0.0002273641,0.00173396,0.969424,0.0005240386,0.01219775,0.00001577632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9325552,0.005591951,0.01647137,0.003874717,0.001540458,0.0001288756,0.01257056,0.00205432,0.02521251],"genre_scores_gemma":[0.9387497,0.001553578,0.007143943,0.0006852879,0.0001355552,0.0001498289,0.006532721,0.0007428617,0.04430661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.016068,"threshold_uncertainty_score":0.05375284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02279161899088151,"score_gpt":0.2916402621339212,"score_spread":0.2688486431430397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}