{"id":"W4320026966","doi":"10.33590/emj/10022165","title":"Tailoring Motor Fluctuation Treatment: Beyond Levodopa Dose Adjustment","year":2022,"lang":"en","type":"article","venue":"European Medical Journal","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Dystonia Coalition; Parkinsonfonden; Allergan; National Institutes of Health; University Health Network Foundation; H. Lundbeck A/S; Jazz Pharmaceuticals; Eisai; University of Oxford; Parkinson Canada; Sunovion; Biogen; International Parkinson and Movement Disorder Society; EVER Neuro Pharma; Ministero dell’Istruzione, dell’Università e della Ricerca; Alexion Pharmaceuticals","keywords":"Levodopa; Parkinson's disease; Medicine; Dopaminergic; Disease; Internal medicine; Dopamine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002661204,0.0006613809,0.0008509086,0.0004910483,0.0004068753,0.00194013,0.000677152,0.001595893,0.003554086],"category_scores_gemma":[0.006683772,0.0002218798,0.001048301,0.0002285372,0.000451316,0.001565638,0.001074239,0.004606379,0.001049993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001013408,"about_ca_system_score_gemma":0.0009057274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00082685,"about_ca_topic_score_gemma":0.001724724,"domain_scores_codex":[0.9989583,0.0004505752,0.00009735605,0.0001344243,0.0002634951,0.00009573284],"domain_scores_gemma":[0.9980412,0.001031056,0.000168283,0.00005665506,0.0004880864,0.0002148693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001843065,0.0006053173,0.002026117,0.001681818,0.0003018527,0.0005570813,0.0006981357,0.002193961,0.007203968,0.006984827,0.1160016,0.8599022],"study_design_scores_gemma":[0.0007730252,0.003751501,0.005529052,0.003209783,0.0006842702,0.001766956,0.0007068883,0.007871032,0.009405222,0.01757475,0.9485319,0.0001955326],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04844242,0.4536484,0.06865195,0.3513325,0.04024962,0.000682759,0.0006466958,0.001491466,0.03485422],"genre_scores_gemma":[0.4563284,0.2401751,0.06239491,0.161164,0.0422001,0.000880921,0.0008817817,0.0007071598,0.03526745],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003554086,"threshold_uncertainty_score":0.01407391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02522282828219048,"score_gpt":0.2712701898684068,"score_spread":0.2460473615862163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}