{"id":"W4320032795","doi":"10.1007/s00441-023-03749-7","title":"Vaccines for prion diseases: a realistic goal?","year":2023,"lang":"en","type":"review","venue":"Cell and Tissue Research","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Saskatchewan","funders":"National Institute of Allergy and Infectious Diseases; Innovation Saskatchewan","keywords":"Chronic wasting disease; Bovine spongiform encephalopathy; Scrapie; Transmissible spongiform encephalopathy; Disease; Immune system; Biology; Prion protein; Virology; Epitope; PRNP; Immunology; Antibody; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005269524,0.0002452174,0.0005290762,0.0001513899,0.0002375671,0.0001013134,0.000313191,0.0002941483,0.00002501441],"category_scores_gemma":[0.0003830593,0.0002005454,0.0002065734,0.0002314142,0.00006548312,0.000002363979,0.0003909507,0.0001798068,0.0000581106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002156733,"about_ca_system_score_gemma":0.0003059358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002711046,"about_ca_topic_score_gemma":0.000007970078,"domain_scores_codex":[0.9981971,0.0002118454,0.0002758449,0.0006307833,0.0002092127,0.0004752113],"domain_scores_gemma":[0.9988909,0.0001931513,0.0000798832,0.0004413039,0.0001369478,0.000257855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002877207,0.00003362724,0.000002805888,0.02579027,0.00005732927,0.00001216558,0.000005311097,2.472286e-7,0.000178837,0.00007167582,0.01086897,0.96295],"study_design_scores_gemma":[0.0002033546,0.0002257565,0.000004085103,0.001699065,0.000160079,0.000005397492,0.00001294599,0.000005783206,0.00007872001,0.0003632066,0.9970081,0.0002334859],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003139181,0.9976959,0.00007287015,0.00002843466,0.00008767261,0.001614233,0.0003300492,0.00002017073,0.0001193373],"genre_scores_gemma":[0.000051734,0.9910362,0.00006285299,0.000006898964,0.0007904712,0.0007610039,0.001342002,0.00008287074,0.005865981],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9861392,"threshold_uncertainty_score":0.8178004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1228022676145572,"score_gpt":0.4611615697131835,"score_spread":0.3383593020986262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}