{"id":"W4320032795","doi":"10.1007/s00441-023-03749-7","title":"Vaccines for prion diseases: a realistic goal?","year":2023,"lang":"en","type":"review","venue":"Cell and Tissue Research","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Saskatchewan","funders":"National Institute of Allergy and Infectious Diseases; Innovation Saskatchewan","keywords":"Chronic wasting disease; Bovine spongiform encephalopathy; Scrapie; Transmissible spongiform encephalopathy; Disease; Immune system; Biology; Prion protein; Virology; Epitope; PRNP; Immunology; Antibody; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007861767,0.001387839,0.001402715,0.0006820181,0.0007029746,0.003770814,0.001461987,0.007943835,0.01875224],"category_scores_gemma":[0.005424236,0.000440739,0.001183595,0.0003501824,0.002142706,0.007646641,0.002505885,0.01001609,0.007097736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001258422,"about_ca_system_score_gemma":0.002118989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005661136,"about_ca_topic_score_gemma":0.0006050348,"domain_scores_codex":[0.9982577,0.0007184719,0.00009394142,0.0001582657,0.0004065992,0.0003650551],"domain_scores_gemma":[0.9959412,0.001573186,0.0003020917,0.0002642717,0.001079539,0.0008398458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001376554,0.0009580598,0.001188683,0.004060788,0.0003971627,0.0009929758,0.0003984499,0.002775722,0.03209864,0.1397774,0.492117,0.3238586],"study_design_scores_gemma":[0.0003071419,0.001328684,0.0005558663,0.001962498,0.0001223321,0.0005663792,0.0003866846,0.0007090503,0.003312601,0.06682417,0.9238651,0.00005954666],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.01063239,0.3805197,0.02224897,0.5329483,0.02782325,0.000305898,0.0008744842,0.0007182864,0.02392884],"genre_scores_gemma":[0.1314878,0.4286579,0.03556959,0.322394,0.03265551,0.001339669,0.002118321,0.0003418323,0.04543544],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01875224,"threshold_uncertainty_score":0.06273252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1228022676145572,"score_gpt":0.4611615697131835,"score_spread":0.3383593020986262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}