{"id":"W4320032914","doi":"10.1038/s41467-023-36465-5","title":"Histone variant H2A.Z modulates nucleosome dynamics to promote DNA accessibility","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Queen's University","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Natural Sciences and Engineering Research Council of Canada; Queen's University; Canada Research Chairs; Compute Canada; Ontario Institute for Cancer Research","keywords":"Nucleosome; Histone; DNA; Histone H2A; Computational biology; Genetics; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002584156,0.0001508674,0.0001397829,0.00007709944,0.0002685799,0.00004711677,0.001367157,0.00033239,0.000008478528],"category_scores_gemma":[0.0001621365,0.0001546225,0.00008320148,0.0003965,0.00007860975,0.000005215147,0.001146439,0.0003410293,0.00005982631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008034191,"about_ca_system_score_gemma":0.00006289125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000155549,"about_ca_topic_score_gemma":0.0007431299,"domain_scores_codex":[0.9990329,0.00004885226,0.0002395492,0.000330365,0.0001104585,0.0002379476],"domain_scores_gemma":[0.9971468,0.0000229245,0.00008243934,0.002491478,0.00014864,0.0001076848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007929983,0.0007653353,0.007583994,0.00008820468,0.0002999228,0.000009808161,0.0007221605,0.001407145,0.9142231,0.04182794,0.01803178,0.01496135],"study_design_scores_gemma":[0.001713485,0.0005669765,0.2951913,0.0001054594,0.0001703608,0.00007795557,0.0005090717,0.2680986,0.02550474,0.01731037,0.3885813,0.002170358],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911431,0.0006499569,0.0004054073,0.005123715,0.0001970113,0.000351386,0.000197469,0.0000871277,0.001844794],"genre_scores_gemma":[0.9867435,0.0003636974,0.009660553,0.0004194084,0.00005646561,0.00005126368,0.001726581,0.0000351502,0.0009434462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8887183,"threshold_uncertainty_score":0.6305321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01109631730519705,"score_gpt":0.2999917378190199,"score_spread":0.2888954205138228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}