{"id":"W4320032914","doi":"10.1038/s41467-023-36465-5","title":"Histone variant H2A.Z modulates nucleosome dynamics to promote DNA accessibility","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Queen's University","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Natural Sciences and Engineering Research Council of Canada; Queen's University; Canada Research Chairs; Compute Canada; Ontario Institute for Cancer Research","keywords":"Nucleosome; Histone; DNA; Histone H2A; Computational biology; Genetics; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001373212,0.0002034283,0.0001683125,0.00009113429,0.0001371908,0.0003692589,0.0003178853,0.0001882094,0.001183286],"category_scores_gemma":[0.000230124,0.00013184,0.0002537632,0.000098378,0.0001812217,0.000256918,0.0002343643,0.0002198318,0.0003552137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002408713,"about_ca_system_score_gemma":0.0002178828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002430689,"about_ca_topic_score_gemma":0.002535919,"domain_scores_codex":[0.9999244,0.000009283499,0.000003020875,0.00002253079,0.00001944604,0.0000213496],"domain_scores_gemma":[0.9999344,0.00001562164,0.00001332033,0.000008151101,0.00001237658,0.00001598868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002538137,0.00002079053,0.004446358,0.0000550834,0.00003377517,0.00007293963,0.00002716991,0.003694931,0.9878904,0.0006412417,0.0001187155,0.002744715],"study_design_scores_gemma":[0.00005478831,0.0002262154,0.0223578,0.00001302607,0.00006522388,0.0001709207,0.0001165319,0.04346619,0.9298536,0.0006135072,0.003033055,0.00002925171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915466,0.000578019,0.006092938,0.00007302814,0.00002257199,0.000006862927,0.0001335636,0.00008809799,0.00145833],"genre_scores_gemma":[0.9989651,0.0001437138,0.0005276399,0.00001437246,0.000002332588,0.000002296196,0.00006031793,0.00001088346,0.0002732567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002430689,"threshold_uncertainty_score":0.004833043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01109631730519705,"score_gpt":0.2999917378190199,"score_spread":0.2888954205138228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}