{"id":"W4320032999","doi":"10.1016/j.celrep.2023.112103","title":"Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute; National Institutes of Health; Ono Medical Research Foundation; Georgia Clinical and Translational Science Alliance; National Center for Advancing Translational Sciences; University of Texas Health Science Center at San Antonio; William and Ella Owens Medical Research Foundation; Cancer Prevention and Research Institute of Texas; National Center for Research Resources; Cancer Research Institute","keywords":"Frizzled; Nitric oxide; Cell biology; Retinoblastoma; Chemistry; Retinoblastoma protein; Biology; Wnt signaling pathway; Biochemistry; Signal transduction; Endocrinology; Gene; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001505068,0.0001686323,0.0001951264,0.0001699941,0.0001275569,0.0002371125,0.0001661553,0.0001556969,0.0007693439],"category_scores_gemma":[0.0001128781,0.00008326172,0.0001649893,0.00007832293,0.000273675,0.0001188478,0.0001842877,0.0004911595,0.0001649053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003015084,"about_ca_system_score_gemma":0.0002202867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008458396,"about_ca_topic_score_gemma":0.001673798,"domain_scores_codex":[0.9998666,0.00002691689,0.00001040855,0.00002637395,0.00003586269,0.00003381683],"domain_scores_gemma":[0.9998741,0.00003275736,0.00003046818,0.0000150398,0.000007565369,0.0000400575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005598038,0.00002670806,0.0001719299,0.00001003761,0.000001723117,0.0000447005,0.000008958194,0.00003402212,0.9989135,0.0001263737,0.00002790148,0.0005782212],"study_design_scores_gemma":[0.00002211689,0.0003100882,0.002038792,0.000003053087,0.000006645091,0.0002871605,0.00003039318,0.001058947,0.9944239,0.00004912535,0.001767407,0.000002344585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962046,0.0007159604,0.001646855,0.000101532,0.0000330814,0.00001575799,0.0001131516,0.00007206292,0.001097074],"genre_scores_gemma":[0.9972041,0.000311877,0.0009885969,0.00002607238,0.000007107367,0.00001184432,0.0001180253,0.000009227224,0.001323182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008458396,"threshold_uncertainty_score":0.002573729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006074629912684651,"score_gpt":0.2230674967476486,"score_spread":0.216992866834964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}