{"id":"W4320033674","doi":"10.1016/j.bbi.2023.02.007","title":"Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells","year":2023,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Menzies Centre for Australian Studies, King's College London, University of London; Medical Research Council; Medical Research Council Centre for Neurodevelopmental Disorders; National Centre for the Replacement, Refinement and Reduction of Animals in Research; King's College London; Canadian Celiac Association; Wellcome Trust","keywords":"Biology; Microglia; Wnt signaling pathway; Progenitor cell; Neural stem cell; Cell biology; Signal transduction; Immunology; Stem cell; Inflammation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001205715,0.0002035981,0.0002284426,0.0003167931,0.0001980597,0.0002993377,0.0000868848,0.0001575355,0.001608564],"category_scores_gemma":[0.0001215055,0.0000726307,0.0002995047,0.0002881616,0.0001937639,0.0001017061,0.00022074,0.0003841403,0.0004555247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001499447,"about_ca_system_score_gemma":0.0002281583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005303146,"about_ca_topic_score_gemma":0.001050176,"domain_scores_codex":[0.999803,0.00001179836,0.00001801682,0.00004686518,0.00007262969,0.00004779143],"domain_scores_gemma":[0.9998921,0.00001365202,0.00003545332,0.00001243195,0.00002068358,0.00002566116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002013025,0.0000225984,0.002406406,0.0000784437,0.00001381635,0.0001053648,0.00004087712,0.00004355578,0.9951533,0.00003006365,0.00007587842,0.001828411],"study_design_scores_gemma":[0.00002383172,0.0005922948,0.1112103,0.00003855387,0.0000628696,0.0008866064,0.0002768492,0.0005964753,0.8826014,0.0001187501,0.003583592,0.000008298774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930959,0.0009724299,0.002102671,0.00006037428,0.00002553387,0.00003495425,0.002391183,0.00008263415,0.001234277],"genre_scores_gemma":[0.9905867,0.000890456,0.003442104,0.0001190905,0.00001700918,0.0001182219,0.003506608,0.00002254339,0.0012973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001608564,"threshold_uncertainty_score":0.005381167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03876467112189081,"score_gpt":0.2862321341453605,"score_spread":0.2474674630234697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}