{"id":"W4320034434","doi":"10.1016/j.jcyt.2023.01.002","title":"T-cell engineered with a fully humanized B-cell maturation antigen-specific T-cell antigen coupler receptor effectively target multiple myeloma","year":2023,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Chimeric antigen receptor; Antigen; TRAC; Multiple myeloma; Receptor; Immunology; Cancer research; T cell; Medicine; Internal medicine; Computer science; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0006855833,0.0006033172,0.0008074502,0.0005936265,0.000283875,0.00014725,0.0003456993,0.0003171735,0.005369435],"category_scores_gemma":[0.00002542613,0.0005086783,0.0002683102,0.001449477,0.0001709967,0.0001951389,0.00004820514,0.0006278162,0.001767995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002805637,"about_ca_system_score_gemma":0.0002332109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003568437,"about_ca_topic_score_gemma":0.00001177077,"domain_scores_codex":[0.9963245,0.0002081582,0.0005105218,0.0009486505,0.0009978069,0.001010299],"domain_scores_gemma":[0.9977944,0.0003568888,0.0001872695,0.0009183967,0.0003935007,0.0003495179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007565944,0.0006153275,0.007637922,0.0001647168,0.000146193,0.0001026497,0.001492487,0.00009595344,0.9608783,0.000008926862,0.01874834,0.002543303],"study_design_scores_gemma":[0.01887446,0.001848597,0.04088204,0.0001016066,0.00001644155,0.00002340968,0.0003480449,0.002972129,0.7717257,0.00001750735,0.1625241,0.000666018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872826,0.001931758,0.002423774,0.0003350149,0.000365456,0.003018278,0.00006398395,0.0007599338,0.003819191],"genre_scores_gemma":[0.9628732,0.005145748,0.004746616,0.0002451939,0.0007322208,0.0002766444,0.0005740158,0.0003869853,0.02501936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1891526,"threshold_uncertainty_score":0.9997365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0196701747012442,"score_gpt":0.2607613006876543,"score_spread":0.2410911259864101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}