{"id":"W4320038736","doi":"10.1101/2023.02.10.528059","title":"Circular mitochondrial-encoded mRNAs are a distinct subpopulation of mitochondrial mRNA in <i>Trypanosoma brucei</i>","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genomics Center, University of Minnesota; University of Minnesota","keywords":"Biology; Trypanosoma brucei; RNA; Circular RNA; Messenger RNA; Molecular biology; Coding region; RNA editing; Cell biology; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002147999,0.0008250302,0.0009825735,0.0004277257,0.0001114614,0.000135577,0.001058811,0.001202535,0.00001687846],"category_scores_gemma":[0.001577493,0.00100021,0.0005608789,0.0006836685,0.0002323638,0.00001960681,0.0009972478,0.0006517022,0.0000335632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000221215,"about_ca_system_score_gemma":0.0008013506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002941234,"about_ca_topic_score_gemma":0.0001091787,"domain_scores_codex":[0.995157,0.0003577179,0.001207864,0.001817367,0.0007114708,0.0007485632],"domain_scores_gemma":[0.995535,0.00005410884,0.001091215,0.002479123,0.0005492949,0.0002912623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001756238,0.0002580816,0.07203119,0.0006016924,0.0002170864,0.0001198262,0.000006051247,0.0004651311,0.9253198,0.00004026969,0.0007641284,0.000001113538],"study_design_scores_gemma":[0.001575049,0.00007755995,0.381177,0.0007479332,0.000194062,8.895121e-8,0.000006410467,0.0001851769,0.6136898,0.00001806013,0.001257385,0.001071469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990227,0.00191485,0.001796936,0.0001052723,0.003527257,0.001354807,0.0008865069,0.0001806793,0.000006720697],"genre_scores_gemma":[0.9954722,0.0002584643,0.00179519,0.00007317206,0.001698957,0.0003814649,0.00002440623,0.0002845373,0.00001163964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.31163,"threshold_uncertainty_score":0.9992448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01621356128162551,"score_gpt":0.2354936914932169,"score_spread":0.2192801302115914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}