{"id":"W4320065022","doi":"10.14309/01.ajg.0000859580.99811.9a","title":"S735 Mirikizumab Improves Quality of Life in Moderately-to-Severely Active UC: Improvement in IBDQ Scores in Participants of LUCENT-1 and LUCENT-2 Randomized, Double-Blind, Placebo-Controlled Phase 3 Trials","year":2022,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Minimal clinically important difference; Randomization; Placebo; Quality of life (healthcare); Inflammatory bowel disease; Crohn's disease; Clinical trial; Maintenance therapy; Internal medicine; Randomized controlled trial; Surgery; Physical therapy; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003385823,0.0008621164,0.002280411,0.000374549,0.000379819,0.0008329783,0.0006657026,0.001425116,0.004806264],"category_scores_gemma":[0.00185274,0.0004833291,0.002060237,0.0004384901,0.0006962682,0.0005799822,0.000308516,0.001278364,0.0005442639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005013589,"about_ca_system_score_gemma":0.0008358534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004389897,"about_ca_topic_score_gemma":0.00129633,"domain_scores_codex":[0.9986249,0.0009024004,0.000127251,0.0001274732,0.0001079443,0.0001099873],"domain_scores_gemma":[0.998975,0.000295847,0.0003610087,0.00005510616,0.00006864872,0.0002444865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9492088,0.003211686,0.001788311,0.001164514,0.001925974,0.00004231131,0.00005768233,0.0001644465,0.006503571,0.00006518491,0.0008193712,0.03504821],"study_design_scores_gemma":[0.8446454,0.1380668,0.01301646,0.0001007546,0.001480102,0.00007342081,0.00002557502,0.0003327175,0.001140383,0.00008469715,0.001009214,0.00002439836],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830928,0.01150762,0.0005123886,0.0005135284,0.0002231921,0.001973173,0.0006531631,0.0001264205,0.001397657],"genre_scores_gemma":[0.9931456,0.002257337,0.0009669355,0.0005888281,0.0001977625,0.001475356,0.0005731004,0.00001118844,0.0007840117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004806264,"threshold_uncertainty_score":0.01790619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03808504105054426,"score_gpt":0.3413277265804298,"score_spread":0.3032426855298855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}