{"id":"W4320169343","doi":"10.1101/2023.02.11.528153","title":"Simple in-vitro single stranded linear and circular DNA preparation and validation via SELEX using phosphor-derived modifications","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institut National de la Recherche Scientifique","funders":"","keywords":"Systematic evolution of ligands by exponential enrichment; DNA; Oligonucleotide; Ligation; Rolling circle replication; Combinatorial chemistry; Computational biology; Chemistry; Molecular biology; Biology; Biochemistry; DNA polymerase; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001638305,0.0008324915,0.0007444282,0.0004326614,0.0003325662,0.0008118988,0.0006638849,0.000520328,0.00235343],"category_scores_gemma":[0.001680657,0.0005113517,0.0004718474,0.0003329526,0.0004351141,0.0004922518,0.0008211193,0.0008264143,0.002001342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002034169,"about_ca_system_score_gemma":0.0003029954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001481566,"about_ca_topic_score_gemma":0.0002658911,"domain_scores_codex":[0.9990256,0.0002455495,0.0001073409,0.0002090795,0.0003234901,0.00008907422],"domain_scores_gemma":[0.9992338,0.0002324901,0.0001345502,0.0001943506,0.0001316048,0.00007305461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008326698,0.00006339332,0.0002256154,0.0001358863,0.00002263957,0.0001339684,0.00007271477,0.0005986064,0.9930292,0.000256871,0.0001240736,0.005253912],"study_design_scores_gemma":[0.000006822661,0.000128423,0.0001631396,0.000004049431,0.00001160791,0.0001070419,0.00001300851,0.00065371,0.9969177,0.00004582522,0.001939318,0.000009266766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7202684,0.001013912,0.2695764,0.0002392371,0.0001625843,0.001018487,0.001367124,0.00190554,0.004448337],"genre_scores_gemma":[0.69438,0.001635707,0.2814209,0.0002015212,0.00003534114,0.001018711,0.004291613,0.0007247676,0.01629137],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.00235343,"threshold_uncertainty_score":0.00866431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02560547849930432,"score_gpt":0.2702353077446611,"score_spread":0.2446298292453568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}