{"id":"W4320480698","doi":"10.1186/s13148-023-01435-7","title":"DNA methylation in peripheral blood leukocytes for the association with glucose metabolism and invasive breast cancer","year":2023,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Nursing Research; University at Buffalo; MedStar Health Research Institute; Wake Forest University; University of Pittsburgh; Ohio State University; National Heart, Lung, and Blood Institute; Brigham and Women's Hospital; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Breast cancer; DNA methylation; Human genetics; Peripheral blood; Cancer; Medicine; Biology; Methylation; Bioinformatics; DNA; Oncology; Internal medicine; Physiology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001119988,0.0001506314,0.0002214604,0.00004241437,0.0001142937,0.00004539456,0.0001279303,0.0002520321,0.000005913559],"category_scores_gemma":[0.0007033497,0.00011053,0.00008842112,0.0002138495,0.00009026502,0.000005222918,0.00007641579,0.0001303839,0.000001812112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001982673,"about_ca_system_score_gemma":0.0001435257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004995689,"about_ca_topic_score_gemma":0.0008485054,"domain_scores_codex":[0.9986172,0.0001571286,0.0004176231,0.0003730976,0.0001668314,0.0002680708],"domain_scores_gemma":[0.9986582,0.0006225441,0.0002084571,0.0002361996,0.0001991991,0.00007542727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003630661,0.000161164,0.7461019,0.00004660972,0.0004144135,0.000002265728,0.0002156433,0.006239663,0.1757335,0.0001932617,0.0002095193,0.07031898],"study_design_scores_gemma":[0.001890903,0.0002910695,0.8705262,0.00001718211,0.0001900754,8.482832e-7,0.00007917961,0.001510572,0.1167391,0.0005776298,0.007957766,0.0002195251],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913341,0.005819328,0.001127492,0.0009797888,0.0002552946,0.0003513075,0.00008219206,0.00001379121,0.00003672142],"genre_scores_gemma":[0.9730117,0.0250001,0.0006588264,0.0002029031,0.0005509065,0.0001357556,0.00008613151,0.00003158806,0.0003220867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1244243,"threshold_uncertainty_score":0.4507282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02763917136676283,"score_gpt":0.3288917756827276,"score_spread":0.3012526043159648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}