{"id":"W4320481402","doi":"10.1016/j.bja.2023.01.008","title":"Distinct pathophysiological characteristics in developing muscle from patients susceptible to malignant hyperthermia","year":2023,"lang":"en","type":"article","venue":"British Journal of Anaesthesia","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"National Center for Research Resources; National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Halothane; Malignant hyperthermia; Caffeine; Myogenesis; Medicine; Internal medicine; Calcium; Endocrinology; Skeletal muscle; Hyperthermia; Anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000164234,0.0002777014,0.0003385567,0.0005308138,0.000284223,0.0003489389,0.0002005828,0.0004193404,0.001917222],"category_scores_gemma":[0.001001141,0.0001461058,0.0002091858,0.0002809865,0.0003487908,0.0001946492,0.0004541996,0.0003840806,0.0002595566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000130139,"about_ca_system_score_gemma":0.00009419834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004981654,"about_ca_topic_score_gemma":0.0004198098,"domain_scores_codex":[0.9998881,0.00001613651,0.00001545192,0.00002335545,0.00002481854,0.00003219332],"domain_scores_gemma":[0.9996151,0.00009856361,0.0001106323,0.00001984754,0.00004451308,0.0001113521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004092635,0.0002483972,0.6052072,0.0001689447,0.0000967454,0.04865316,0.001820622,0.0002660406,0.3262434,0.0004531145,0.0002135201,0.01253609],"study_design_scores_gemma":[0.00002355768,0.0009871392,0.970501,0.00001219235,0.00003218547,0.02444101,0.0004979334,0.0001662328,0.002953953,0.00009293469,0.0002847269,0.00000706518],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992156,0.0001457023,0.0001154589,0.00002883141,0.000006944434,0.00000659418,0.00003760762,0.000002474651,0.0004408098],"genre_scores_gemma":[0.9993011,0.0001209086,0.00008786914,0.00002623132,0.00001450309,0.00000756534,0.000141336,0.000002823491,0.0002977506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001917222,"threshold_uncertainty_score":0.006413698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01410668790825831,"score_gpt":0.2291676528320467,"score_spread":0.2150609649237884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}