{"id":"W4320481405","doi":"10.1021/acs.molpharmaceut.2c00783","title":"Characterization of PGua<sub>4</sub>, a Guanidinium-Rich Peptoid that Delivers IgGs to the Cytosol via Macropinocytosis","year":2023,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec","keywords":"Pinocytosis; Peptoid; Endocytosis; Internalization; Chemistry; Endosome; Cytosol; Cytoplasm; Intracellular; Biophysics; Cell biology; HEK 293 cells; Confocal microscopy; Cell membrane; Clathrin; Intravasation; Proteolysis; Biochemistry; Cell; Cancer cell; Biology; Peptide; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002162659,0.0002607988,0.0002031527,0.0001297521,0.0001212443,0.00003892077,0.000494522,0.0001526335,0.00001862289],"category_scores_gemma":[0.00003458919,0.000232893,0.0001729551,0.000488915,0.0000709395,0.000009196552,0.0003442027,0.0001473848,0.0002104118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002417831,"about_ca_system_score_gemma":0.00006310657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009076721,"about_ca_topic_score_gemma":0.0000101085,"domain_scores_codex":[0.9984063,0.0001216576,0.0002944713,0.0004392412,0.0003189449,0.0004193995],"domain_scores_gemma":[0.9989935,0.00001240388,0.0001380458,0.0005309278,0.0001924235,0.0001327424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001072619,0.00004066831,0.0006692693,0.00003218769,0.0001468645,0.00001902016,0.0002105786,0.0003613154,0.9900315,0.00000813458,0.001068039,0.007305181],"study_design_scores_gemma":[0.0003721055,0.0001831346,0.001118518,0.00002126205,0.00008223976,0.00001437427,0.0001012997,0.0008048054,0.9824636,0.000007948344,0.01456221,0.000268513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873409,0.0001876102,0.01066399,0.0006920763,0.0003664986,0.0004626158,0.0001058983,0.00004138691,0.0001389905],"genre_scores_gemma":[0.9953265,0.001487814,0.00006972262,0.002319606,0.0001383993,0.00006164044,0.0004272176,0.00005199767,0.000117169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01349417,"threshold_uncertainty_score":0.9497102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02495602191616364,"score_gpt":0.2796159652069737,"score_spread":0.25465994329081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}