{"id":"W4320481405","doi":"10.1021/acs.molpharmaceut.2c00783","title":"Characterization of PGua<sub>4</sub>, a Guanidinium-Rich Peptoid that Delivers IgGs to the Cytosol via Macropinocytosis","year":2023,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec","keywords":"Pinocytosis; Peptoid; Endocytosis; Internalization; Chemistry; Endosome; Cytosol; Cytoplasm; Intracellular; Biophysics; Cell biology; HEK 293 cells; Confocal microscopy; Cell membrane; Clathrin; Intravasation; Proteolysis; Biochemistry; Cell; Cancer cell; Biology; Peptide; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001405221,0.0002099135,0.0001517277,0.0001650123,0.0000949129,0.0001937746,0.0001249662,0.000222297,0.0002922381],"category_scores_gemma":[0.0002688532,0.00006627601,0.0001366634,0.0001140286,0.0001917484,0.0001526396,0.0001145001,0.0002105138,0.0001326535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002775489,"about_ca_system_score_gemma":0.0002587459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001092382,"about_ca_topic_score_gemma":0.0006139191,"domain_scores_codex":[0.999947,0.00001146643,0.000003483636,0.000009313167,0.00001771868,0.00001099312],"domain_scores_gemma":[0.9998971,0.00003174551,0.00002348187,0.000007312831,0.00002096899,0.00001934857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002182701,0.000004950301,0.0002260611,0.00001836135,0.000001879933,0.00003469934,0.000006365011,0.00009909728,0.9988758,0.00003931006,0.000005380906,0.0006662267],"study_design_scores_gemma":[0.000004275625,0.0001591278,0.003262322,0.000002801882,0.000007014388,0.0001953453,0.00001317895,0.00120348,0.9938005,0.00003213978,0.001316365,0.00000352358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886524,0.0008156611,0.009542057,0.00004929376,0.000007598046,0.00004574545,0.0001781325,0.00003399471,0.0006750644],"genre_scores_gemma":[0.9820338,0.0006145348,0.0152066,0.00006602707,0.000006043695,0.00005117591,0.0005975312,0.00001753924,0.001406842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001092382,"threshold_uncertainty_score":0.002172053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02495602191616364,"score_gpt":0.2796159652069737,"score_spread":0.25465994329081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}