{"id":"W4320481574","doi":"10.21037/cco-22-108","title":"Pancreatic adenocarcinomas without KRAS, TP53, CDKN2A and SMAD4 mutations and CDKN2A/CDKN2B copy number alterations: a review of the genomic landscape to unveil therapeutic avenues","year":2023,"lang":"en","type":"review","venue":"Chinese Clinical Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Sault Area Hospital","funders":"","keywords":"CDKN2A; KRAS; Pancreatic cancer; CDKN2B; Pancreatic Intraepithelial Neoplasia; Adenocarcinoma; Medicine; Cancer research; Disease; Microsatellite instability; Molecular pathology; Cancer; Bioinformatics; Oncology; Pathology; Internal medicine; Biology; Gene; Genetics; Allele; Colorectal cancer; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001110012,0.0004670791,0.0008536974,0.004716954,0.0002532276,0.000948077,0.0004800798,0.0004081676,0.001081145],"category_scores_gemma":[0.001842784,0.0002211175,0.0007512906,0.003779727,0.0003619603,0.0009125993,0.000518475,0.0005774879,0.0004841623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004135248,"about_ca_system_score_gemma":0.0008818553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001369153,"about_ca_topic_score_gemma":0.002330638,"domain_scores_codex":[0.9995474,0.00007921848,0.0001096335,0.0001072177,0.0001202675,0.00003621384],"domain_scores_gemma":[0.9988006,0.0005422898,0.0002536472,0.0000585233,0.0002813357,0.00006353329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003271199,0.00003503653,0.01709753,0.01760052,0.0004768011,0.001491424,0.0001985455,0.0003988518,0.003134468,0.00131927,0.0215969,0.9363236],"study_design_scores_gemma":[0.00002723734,0.0003173996,0.1127001,0.01915634,0.002270399,0.03015504,0.0006553372,0.00062481,0.003598271,0.003976981,0.8264099,0.0001082528],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00476731,0.991785,0.0007503472,0.000597027,0.0001692741,0.0000122197,0.0004086048,0.00004207057,0.001468115],"genre_scores_gemma":[0.0246572,0.9709026,0.001634741,0.0004587182,0.0003498295,0.00002051232,0.001284996,0.00001983229,0.0006715624],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004716954,"threshold_uncertainty_score":0.005870402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1784333859995173,"score_gpt":0.5289050003066107,"score_spread":0.3504716143070934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}