{"id":"W4320481574","doi":"10.21037/cco-22-108","title":"Pancreatic adenocarcinomas without KRAS, TP53, CDKN2A and SMAD4 mutations and CDKN2A/CDKN2B copy number alterations: a review of the genomic landscape to unveil therapeutic avenues","year":2023,"lang":"en","type":"review","venue":"Chinese Clinical Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Sault Area Hospital","funders":"","keywords":"CDKN2A; KRAS; Pancreatic cancer; CDKN2B; Pancreatic Intraepithelial Neoplasia; Adenocarcinoma; Medicine; Cancer research; Disease; Microsatellite instability; Molecular pathology; Cancer; Bioinformatics; Oncology; Pathology; Internal medicine; Biology; Gene; Genetics; Allele; Colorectal cancer; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002577871,0.0005495118,0.005780566,0.0001950149,0.0002090107,0.00002415352,0.0003904366,0.0007289771,0.0002408561],"category_scores_gemma":[0.005403862,0.0003145304,0.0005738078,0.0008581365,0.0009122035,0.00004488857,0.0004320043,0.001248064,0.0002853468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000170773,"about_ca_system_score_gemma":0.002891813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005429784,"about_ca_topic_score_gemma":0.0001117441,"domain_scores_codex":[0.9940788,0.001876449,0.002403783,0.0008060397,0.0003562815,0.0004786176],"domain_scores_gemma":[0.9905509,0.006844719,0.0008775222,0.0009340211,0.0003137738,0.0004790872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002239639,0.0006515796,0.5634557,0.08726302,0.002415675,0.0001386817,0.0004501249,1.898066e-7,0.000002045429,0.0002561364,0.005698882,0.339444],"study_design_scores_gemma":[0.00325191,0.002195635,0.1836166,0.06485067,0.01425171,0.001454702,0.00007671717,0.00009882907,1.385557e-7,0.001071351,0.7285469,0.0005848703],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.017014,0.9738937,0.00001824686,0.002819617,0.0003941746,0.004062379,0.0001343209,0.00005324137,0.001610326],"genre_scores_gemma":[0.002328641,0.9904398,0.0006919104,0.00240996,0.000618149,0.0007856583,0.0002658417,0.00009842427,0.002361636],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.722848,"threshold_uncertainty_score":0.9999307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1784333859995173,"score_gpt":0.5289050003066107,"score_spread":0.3504716143070934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}